PMID- 16817957
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20070716
LR  - 20200929
IS  - 1477-9560 (Electronic)
IS  - 1477-9560 (Linking)
VI  - 4
DP  - 2006 Jul 3
TI  - An update on prevention of venous thromboembolism in hospitalized acutely ill 
      medical patients.
PG  - 8
AB  - Both the recently updated consensus guidelines published by the American College 
      of Chest Physicians, and the International Union of Angiology recommend 
      thromboprophylaxis with either low-molecular-weight heparin (LMWH) or 
      unfractionated heparin (UFH) in medical patients at risk of VTE. However, no 
      guidance is given regarding the appropriate dosing regimens that should be used 
      for thromboprophylaxis in this patient group. LMWH (enoxaparin and dalteparin) 
      and UFH have been shown to be effective for thromboprophylaxis in at-risk 
      hospitalized medical patients. Although LMWH once daily (o.d.) has been shown to 
      be as effective as UFH three times daily (t.i.d.) for thromboprophylaxis in 
      at-risk medical patients, there are no data to show that UFH twice daily (b.i.d) 
      is as effective as either LMWH o.d. or UFH t.i.d. On the basis of currently 
      available evidence, the LMWHs enoxaparin and dalteparin are more attractive 
      alternatives to UFH for the prevention of VTE in hospitalized medical patients 
      because of their convenient once-daily administration and better safety profile, 
      demonstrated in terms of reduced bleeding, HIT, and other adverse events.
FAU - Samama, Meyer Michel
AU  - Samama MM
AD  - Department d'Hematologie Biologique, Hotel Dieu, Paris, France. 
      m.samama@lablcl.com
FAU - Kleber, Franz-Xaver
AU  - Kleber FX
LA  - eng
PT  - Journal Article
DEP - 20060703
PL  - England
TA  - Thromb J
JT  - Thrombosis journal
JID - 101170542
PMC - PMC1550384
EDAT- 2006/07/05 09:00
MHDA- 2006/07/05 09:01
PMCR- 2006/07/03
CRDT- 2006/07/05 09:00
PHST- 2005/11/03 00:00 [received]
PHST- 2006/07/03 00:00 [accepted]
PHST- 2006/07/05 09:00 [pubmed]
PHST- 2006/07/05 09:01 [medline]
PHST- 2006/07/05 09:00 [entrez]
PHST- 2006/07/03 00:00 [pmc-release]
AID - 1477-9560-4-8 [pii]
AID - 10.1186/1477-9560-4-8 [doi]
PST - epublish
SO  - Thromb J. 2006 Jul 3;4:8. doi: 10.1186/1477-9560-4-8.