PMID- 16818127
OWN - NLM
STAT- MEDLINE
DCOM- 20060801
LR  - 20071115
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 25
IP  - 7
DP  - 2006 Jul
TI  - Fish oils produce anti-inflammatory effects and improve body weight in severe 
      heart failure.
PG  - 834-8
AB  - BACKGROUND: Fish oils have been shown to reduce production of tumor necrosis 
      factor-alpha (TNF-alpha) in healthy subjects. We sought to evaluate the effects 
      of fish oils on pro-inflammatory cytokines and body weight in patients with 
      advanced heart failure. METHODS: Fourteen patients (New York Heart Association 
      [NYHA] Class III to IV heart failure) were randomized in a double-blinded trial 
      to active therapy with 8 g of n-3 fatty acids (Group A, n = 7) or placebo (Group 
      B, n = 7) for 18 weeks. TNF-alpha and interleukin-1 (IL-1) production were 
      measured by radioimmunoassay after endotoxin stimulation of peripheral blood 
      mononuclear cells. RESULTS: Placebo-treated patients had a 44% increase in 
      TNF-alpha (from 1.28 to 1.84 pg/ml; p = 0.07) but no significant change in IL-1 
      (from 0.68 to 0.78 pg/ml) production. n-3 fatty acids resulted in a 59% reduction 
      in TNF-alpha (from 1.64 to 0.68 pg/ml; p = 0.02) and 39% decrease in IL-1 (from 
      1.98 to 1.21 pg/ml; p = 0.09) production. There was an inverse correlation 
      between change in TNF-alpha production and change in percent body fat (r = -0.6; 
      p = 0.02). CONCLUSIONS: Fish oils decrease TNF-alpha production in heart failure 
      and improve body weight. Fish oil therapy may represent a novel therapeutic 
      approach in late-stage heart failure characterized by cardiac cachexia.
FAU - Mehra, Mandeep R
AU  - Mehra MR
AD  - Division of Cardiology, Department of Medicine, University of Maryland School of 
      Medicine, Baltimore, Maryland 21201, USA. mmehra@medicine.umaryland.edu
FAU - Lavie, Carl J
AU  - Lavie CJ
FAU - Ventura, Hector O
AU  - Ventura HO
FAU - Milani, Richard V
AU  - Milani RV
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20060524
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fish Oils)
RN  - 0 (Interleukin-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adipose Tissue/pathology
MH  - Aged
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Body Weight/*drug effects
MH  - Double-Blind Method
MH  - Fatty Acids/blood
MH  - Fatty Acids, Omega-3/*therapeutic use
MH  - Female
MH  - Fish Oils/*therapeutic use
MH  - Heart Failure/blood/*drug therapy/pathology/*physiopathology
MH  - Humans
MH  - Interleukin-1/blood
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/biosynthesis/metabolism
EDAT- 2006/07/05 09:00
MHDA- 2006/08/02 09:00
CRDT- 2006/07/05 09:00
PHST- 2005/11/22 00:00 [received]
PHST- 2006/02/12 00:00 [revised]
PHST- 2006/03/06 00:00 [accepted]
PHST- 2006/07/05 09:00 [pubmed]
PHST- 2006/08/02 09:00 [medline]
PHST- 2006/07/05 09:00 [entrez]
AID - S1053-2498(06)00221-X [pii]
AID - 10.1016/j.healun.2006.03.005 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2006 Jul;25(7):834-8. doi: 10.1016/j.healun.2006.03.005. 
      Epub 2006 May 24.