PMID- 16819169
OWN - NLM
STAT- MEDLINE
DCOM- 20060913
LR  - 20190720
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 29
IP  - 7
DP  - 2006 Jul
TI  - Inhibition of anaphylaxis-like reaction and mast cell activation by water extract 
      from the fruiting body of Phellinus linteus.
PG  - 1360-5
AB  - Mast cell-mediated anaphylactic reaction is involved in many allergic diseases 
      such as asthma and allergic rhinitis. Phellinus linteus has been used as a 
      traditional herb medicine in oriental countries and is known to have anti-tumor, 
      immunomodulatory, anti-inflammatory, and anti-allergic activities. However, roles 
      of Phellinus linteus in the mast cell-mediated anaphylactic reactions have not 
      fully been examined. In the present study, we have investigated the effects of 
      water extract from the fruiting body of Phellinus linteus (WEPL) on mast 
      cell-mediated anaphylaxis-like reactions. Oral administration of WEPL inhibited 
      the compound 48/80-induced systemic anaphylaxis-like reaction and ear swelling 
      response. WEPL also inhibited the anti-dinitrophenyl (DNP) IgE-mediated passive 
      systemic and cutaneous anaphylaxis. WEPL had no cytotoxicity on rat peritoneal 
      mast cells (RPMC). WEPL dose-dependently reduced histamine release from RPMC 
      activated by compound 48/80 or anti-DNP IgE. Moreover, WEPL decreased the 
      compound 48/80-induced calcium uptake into RPMC. Furthermore, WEPL increased the 
      level of intracellular cAMP and significantly inhibited the compound 
      48/80-induced cAMP reduction in RPMC. These results suggest that WEPL may serve 
      as an effective therapeutic agent for allergic diseases.
FAU - Choi, Yun Ho
AU  - Choi YH
AD  - Department of Anatomy, Chonbuk National University Medical School, Jeonbuk, 
      Republic of Korea.
FAU - Yan, Guang Hai
AU  - Yan GH
FAU - Chai, Ok Hee
AU  - Chai OH
FAU - Lim, Jung Min
AU  - Lim JM
FAU - Sung, So Young
AU  - Sung SY
FAU - Zhang, Xin
AU  - Zhang X
FAU - Kim, Ji-Hyun
AU  - Kim JH
FAU - Choi, Su Hwan
AU  - Choi SH
FAU - Lee, Moo Sam
AU  - Lee MS
FAU - Han, Eui-Hyeog
AU  - Han EH
FAU - Kim, Hyoung Tae
AU  - Kim HT
FAU - Song, Chang Ho
AU  - Song CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Pharmaceutical Preparations)
RN  - 059QF0KO0R (Water)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Anaphylaxis/*prevention & control
MH  - Animals
MH  - *Basidiomycota
MH  - Calcium/metabolism
MH  - Cell Survival/drug effects
MH  - Disease Models, Animal
MH  - Histamine Release/drug effects
MH  - Mast Cells/drug effects/*physiology
MH  - Mice
MH  - Pharmaceutical Preparations/isolation & purification
MH  - Water
EDAT- 2006/07/05 09:00
MHDA- 2006/09/14 09:00
CRDT- 2006/07/05 09:00
PHST- 2006/07/05 09:00 [pubmed]
PHST- 2006/09/14 09:00 [medline]
PHST- 2006/07/05 09:00 [entrez]
AID - JST.JSTAGE/bpb/29.1360 [pii]
AID - 10.1248/bpb.29.1360 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2006 Jul;29(7):1360-5. doi: 10.1248/bpb.29.1360.