PMID- 16819170
OWN - NLM
STAT- MEDLINE
DCOM- 20060913
LR  - 20190720
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 29
IP  - 7
DP  - 2006 Jul
TI  - Inhibitory effects of Agaricus blazei on mast cell-mediated anaphylaxis-like 
      reactions.
PG  - 1366-71
AB  - Agaricus blazei is a medicinal mushroom native to Brazil. It used to be a source 
      of anti-tumor and immunmoactive compounds and considered a health food in many 
      countries. However, its specific effect against mast cell-mediated anaphylactic 
      reactions is still unknown. In the present study, we investigated the effect of 
      Agaricus blazei water extract (ABWE) on mast cell-mediated anaphylaxis-like 
      reactions. We examined whether ABWE could inhibit systemic anaphylaxis-like 
      reaction, ear swelling response, passive cutaneous anaphylaxis, and mast cell 
      activation. ABWE inhibited compound 48/80-induced systemic anaphylaxis-like 
      reaction, ear swelling response, and passive cutaneous anaphylaxis-like reaction 
      in mice. ABWE also inhibited anti-dinitrophenyl (DNP) IgE-mediated passive 
      cutaneous anaphylaxis. ABWE dose-dependently inhibited compound 48/80-induced or 
      anti-DNP IgE-mediated histamine release from rat peritoneal mast cells (RPMC). 
      Moreover, pretreatment with ABWE reduced compound 48/80-induced calcium uptake 
      into RPMC. When ABWE was added, the level of intracellular cAMP in RPMC showed a 
      significant increase compared with that of control cells. In addition, ABWE 
      significantly inhibited compound 48/80-induced cAMP reduction in RPMC. These 
      results propose that ABWE may be beneficial in the treatment of mast 
      cell-mediated anaphylactic reactions.
FAU - Choi, Yun Ho
AU  - Choi YH
AD  - Department of Anatomy, Chonbuk National University Medical School, Jeonbuk, 
      Republic of Kora.
FAU - Yan, Guang Hai
AU  - Yan GH
FAU - Chai, Ok Hee
AU  - Chai OH
FAU - Choi, Yung Hyun
AU  - Choi YH
FAU - Zhang, Xin
AU  - Zhang X
FAU - Lim, Jung Min
AU  - Lim JM
FAU - Kim, Ji-Hyun
AU  - Kim JH
FAU - Lee, Moo Sam
AU  - Lee MS
FAU - Han, Eui-Hyeog
AU  - Han EH
FAU - Kim, Hyoung Tae
AU  - Kim HT
FAU - Song, Chang Ho
AU  - Song CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - *Agaricus
MH  - Anaphylaxis/chemically induced/*prevention & control
MH  - Animals
MH  - Calcium/*metabolism
MH  - Ear
MH  - Edema/prevention & control
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E/immunology
MH  - Mast Cells/drug effects/*physiology
MH  - Mice
MH  - Plant Extracts/*pharmacology
MH  - *Plants, Medicinal
MH  - p-Methoxy-N-methylphenethylamine
EDAT- 2006/07/05 09:00
MHDA- 2006/09/14 09:00
CRDT- 2006/07/05 09:00
PHST- 2006/07/05 09:00 [pubmed]
PHST- 2006/09/14 09:00 [medline]
PHST- 2006/07/05 09:00 [entrez]
AID - JST.JSTAGE/bpb/29.1366 [pii]
AID - 10.1248/bpb.29.1366 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2006 Jul;29(7):1366-71. doi: 10.1248/bpb.29.1366.