PMID- 16819504
OWN - NLM
STAT- MEDLINE
DCOM- 20070208
LR  - 20210118
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 26
IP  - 2
DP  - 2007 Jan 11
TI  - Evidence that MIG-6 is a tumor-suppressor gene.
PG  - 269-76
AB  - Mitogen-inducible gene 6 (MIG-6) is located in human chromosome 1p36, a locus 
      frequently associated with human lung cancer. MIG-6 is a negative regulator of 
      epidermal growth factor (EGF) signaling, and we show that Mig-6 - like EGF - is 
      induced by hepatocyte growth factor/scatter factor (HGF/SF) in human lung cancer 
      cell lines. Frequently, the receptors for both factors, EGFR and Met, are 
      expressed in same lung cancer cell line, and MIG-6 is induced by both factors in 
      a mitogen-activated protein kinase-dependent fashion. However, not all tumor 
      lines express MIG-6 in response to either EGF or HGF/SF. In these cases, we find 
      missense and nonsense mutations in the MIG-6 coding region, as well as evidence 
      for MIG-6 transcriptional silencing. Moreover, germline disruption of Mig-6 in 
      mice leads to the development of animals with epithelial hyperplasia, adenoma, 
      and adenocarcinoma in organs like the lung, gallbladder, and bile duct. These 
      data suggests that MIG-6 is a tumor-suppressor gene and is therefore a candidate 
      gene for the frequent 1p36 genetic alterations found in lung cancer.
FAU - Zhang, Y-W
AU  - Zhang YW
AD  - Laboratory of Molecular Oncology, Van Andel Research Institute, Grand Rapids, MI 
      49503, USA. yu-wen.zhang@vai.org
FAU - Staal, B
AU  - Staal B
FAU - Su, Y
AU  - Su Y
FAU - Swiatek, P
AU  - Swiatek P
FAU - Zhao, P
AU  - Zhao P
FAU - Cao, B
AU  - Cao B
FAU - Resau, J
AU  - Resau J
FAU - Sigler, R
AU  - Sigler R
FAU - Bronson, R
AU  - Bronson R
FAU - Vande Woude, G F
AU  - Vande Woude GF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060703
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Codon, Nonsense)
RN  - 0 (ERRFI1 protein, human)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/genetics/*physiology
MH  - Adenocarcinoma/etiology/metabolism/pathology
MH  - Adenoma/etiology/metabolism/pathology
MH  - Animals
MH  - Bile Duct Neoplasms/etiology/metabolism/pathology
MH  - Blotting, Northern
MH  - Blotting, Western
MH  - Carcinoma, Non-Small-Cell Lung/metabolism/pathology
MH  - Carcinoma, Squamous Cell/metabolism/pathology
MH  - Codon, Nonsense/*genetics
MH  - Epithelial Cells/pathology
MH  - ErbB Receptors
MH  - Gallbladder Diseases/etiology/metabolism/pathology
MH  - Gene Expression Regulation, Neoplastic
MH  - Genes, Tumor Suppressor/*physiology
MH  - Hepatocyte Growth Factor/pharmacology
MH  - Humans
MH  - Hyperplasia/etiology/metabolism/pathology
MH  - Immunoenzyme Techniques
MH  - Lung Neoplasms/metabolism/*pathology
MH  - Mice
MH  - Mice, Knockout
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Mutation, Missense/*genetics
MH  - Signal Transduction
MH  - Tumor Cells, Cultured
MH  - Tumor Suppressor Proteins
EDAT- 2006/07/05 09:00
MHDA- 2007/02/09 09:00
CRDT- 2006/07/05 09:00
PHST- 2006/07/05 09:00 [pubmed]
PHST- 2007/02/09 09:00 [medline]
PHST- 2006/07/05 09:00 [entrez]
AID - 1209790 [pii]
AID - 10.1038/sj.onc.1209790 [doi]
PST - ppublish
SO  - Oncogene. 2007 Jan 11;26(2):269-76. doi: 10.1038/sj.onc.1209790. Epub 2006 Jul 3.