PMID- 16819522
OWN - NLM
STAT- MEDLINE
DCOM- 20060927
LR  - 20200204
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 9
IP  - 8
DP  - 2006 Aug
TI  - BDNF-mediated neurotransmission relies upon a myosin VI motor complex.
PG  - 1009-18
AB  - Brain-derived neurotrophic factor (BDNF) has been implicated in higher-order 
      cognitive functions and in psychiatric disorders such as depression and 
      schizophrenia. BDNF modulates synaptic transmission and plasticity primarily 
      through the TrkB receptor, but the molecules involved in BDNF-mediated synaptic 
      modulation are largely unknown. Myosin VI (Myo6) is a minus end-directed 
      actin-based motor found in neurons that express Trk receptors. Here we report 
      that Myo6 and a Myo6-binding protein, GIPC1, form a complex that can engage TrkB. 
      Myo6 and GIPC1 were necessary for BDNF-TrkB-mediated facilitation of long-term 
      potentiation in postnatal day 12-13 (P12-13) hippocampus. Moreover, BDNF-mediated 
      enhancement of glutamate release from presynaptic terminals depended not only 
      upon TrkB but also upon Myo6 and GIPC1. Similar defects in basal synaptic 
      transmission as well as presynaptic properties were observed in Myo6 and GIPC1 
      mutant mice. Together, these results define an important role for the Myo6-GIPC1 
      motor complex in presynaptic function and in BDNF-TrkB-mediated synaptic 
      plasticity.
FAU - Yano, Hiroko
AU  - Yano H
AD  - Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, 
      Departments of Cell Biology, Physiology and Neuroscience, New York University 
      School of Medicine, 540 First Avenue, New York, New York 10016, USA.
FAU - Ninan, Ipe
AU  - Ninan I
FAU - Zhang, Hong
AU  - Zhang H
FAU - Milner, Teresa A
AU  - Milner TA
FAU - Arancio, Ottavio
AU  - Arancio O
FAU - Chao, Moses V
AU  - Chao MV
LA  - eng
GR  - DA08259/DA/NIDA NIH HHS/United States
GR  - HD23315/HD/NICHD NIH HHS/United States
GR  - HL-18974/HL/NHLBI NIH HHS/United States
GR  - NS21072/NS/NINDS NIH HHS/United States
GR  - NS40045/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060702
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carrier Proteins)
RN  - 0 (Gipc1 protein, mouse)
RN  - 0 (Gipc1 protein, rat)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Neuropeptides)
RN  - 0 (myosin VI)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 3.6.4.1 (Myosin Heavy Chains)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Carrier Proteins/genetics/*metabolism
MH  - Hippocampus/cytology/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Multiprotein Complexes
MH  - Myosin Heavy Chains/genetics/*metabolism
MH  - Neuronal Plasticity/physiology
MH  - Neurons/metabolism/ultrastructure
MH  - Neuropeptides/genetics/*metabolism
MH  - Patch-Clamp Techniques
MH  - Rats
MH  - Receptor, trkB/metabolism
MH  - Synapses/physiology
MH  - Synaptic Transmission/*physiology
EDAT- 2006/07/05 09:00
MHDA- 2006/09/28 09:00
CRDT- 2006/07/05 09:00
PHST- 2006/04/03 00:00 [received]
PHST- 2006/05/30 00:00 [accepted]
PHST- 2006/07/05 09:00 [pubmed]
PHST- 2006/09/28 09:00 [medline]
PHST- 2006/07/05 09:00 [entrez]
AID - nn1730 [pii]
AID - 10.1038/nn1730 [doi]
PST - ppublish
SO  - Nat Neurosci. 2006 Aug;9(8):1009-18. doi: 10.1038/nn1730. Epub 2006 Jul 2.