PMID- 16819981
OWN - NLM
STAT- MEDLINE
DCOM- 20060928
LR  - 20231024
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 23
IP  - 11
DP  - 2006 Jun
TI  - Biochemical and electrophysiological changes of substantia nigra pars reticulata 
      driven by subthalamic stimulation in patients with Parkinson's disease.
PG  - 2923-8
AB  - To understand the events underlying the clinical efficacy of deep brain 
      stimulation (DBS) of the subthalamic nucleus (STN), electrophysiological 
      recordings and microdialysis evaluations were carried out in the substantia nigra 
      pars reticulata (SNr), one of the two basal ganglia (BG) nuclei targeted by STN 
      output, in patients with Parkinson's disease (PD). Clinically effective STN-DBS 
      caused a significant increase of the SNr firing rate. The poststimulus histogram 
      (PSTH) showed an excitation peak at 1.92-3.85 ms after the STN stimulus. The 
      spontaneous discharge of SNr neurons was driven at the frequency of the 
      stimulation (130 Hz), as shown in the autocorrelograms (AutoCrl). The fast 
      Fourier transform (FFT) analysis showed a peak at 130 Hz, and a less pronounced 
      second one at 260 Hz. Accordingly, in the distribution of the interspike 
      intervals (ISIs), the mode was earlier, and skewness more asymmetric. 
      Biochemically, the increased excitatory driving from the STN was reflected by a 
      clear-cut increase in cyclic guanosine 3',5'-monophosphate (cGMP) levels in the 
      SNr. These results indicate that the beneficial effect of DBS in PD patients is 
      paralleled with a stimulus-synchronized activation of the STN target, SNr. Our 
      findings suggest that, during STN-DBS, a critical change towards a high-frequency 
      oscillatory discharge occurs.
FAU - Galati, Salvatore
AU  - Galati S
AD  - I.R.C.C.S. Fondazione S., Via Ardeatina 306-00133, Rome, Italy.
FAU - Mazzone, Paolo
AU  - Mazzone P
FAU - Fedele, Ernesto
AU  - Fedele E
FAU - Pisani, Antonio
AU  - Pisani A
FAU - Peppe, Antonella
AU  - Peppe A
FAU - Pierantozzi, Mariangela
AU  - Pierantozzi M
FAU - Brusa, Livia
AU  - Brusa L
FAU - Tropepi, Domenicantonio
AU  - Tropepi D
FAU - Moschella, Vincenzo
AU  - Moschella V
FAU - Raiteri, Maurizio
AU  - Raiteri M
FAU - Stanzione, Paolo
AU  - Stanzione P
FAU - Bernardi, Giorgio
AU  - Bernardi G
FAU - Stefani, Alessandro
AU  - Stefani A
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Action Potentials/radiation effects
MH  - Aged
MH  - Analysis of Variance
MH  - Brain Chemistry/*physiology
MH  - Cyclic GMP/metabolism
MH  - Deep Brain Stimulation/*methods
MH  - Female
MH  - Fourier Analysis
MH  - Humans
MH  - Male
MH  - Microdialysis/methods/statistics & numerical data
MH  - Middle Aged
MH  - *Parkinson Disease/metabolism/physiopathology/therapy
MH  - Substantia Nigra/*metabolism/*physiopathology
MH  - Subthalamic Nucleus/*radiation effects
MH  - Time Factors
EDAT- 2006/07/06 09:00
MHDA- 2006/09/29 09:00
CRDT- 2006/07/06 09:00
PHST- 2006/07/06 09:00 [pubmed]
PHST- 2006/09/29 09:00 [medline]
PHST- 2006/07/06 09:00 [entrez]
AID - EJN4816 [pii]
AID - 10.1111/j.1460-9568.2006.04816.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2006 Jun;23(11):2923-8. doi: 10.1111/j.1460-9568.2006.04816.x.