PMID- 16820034
OWN - NLM
STAT- MEDLINE
DCOM- 20060822
LR  - 20141120
IS  - 0303-6979 (Print)
IS  - 0303-6979 (Linking)
VI  - 33
IP  - 7
DP  - 2006 Jul
TI  - Enhanced susceptibility to periodontitis in an animal model of depression: 
      reversed by chronic treatment with the anti-depressant tianeptine.
PG  - 469-77
AB  - OBJECTIVE: To test the hypothesis that the olfactory bulbectomy model of 
      depression in rats could influence susceptibility to ligature-induced 
      periodontitis, and that chronic treatment with the anti-depressant drug 
      tianeptine could attenuate this effect. MATERIAL AND METHODS: Tianeptine was 
      given twice daily (10 mg/kg, i.p.) during the entire experiment, starting 29 days 
      before induction of olfactory bulbectomy and periodontitis. Olfactory 
      bulbectomized (OB) rats and sham-operated rats were given saline in a similar 
      manner. Periodontal disease was assessed when the ligatures had been in place for 
      21 days. Two hours before decapitation, rats were injected with 
      lipopolysaccharide (LPS;100 microg/kg, i.p.) to induce a robust immune and stress 
      response. RESULTS: Compared with sham-operated controls, OB rats developed 
      significantly more periodontal bone loss, exhibited characteristic behavioural 
      responses in a novel open field test, and showed a decreased expression of 
      glucocorticoid receptors (GRs) in the hippocampus. LPS provoked a significantly 
      larger increase in circulating levels of the stress hormone corticosterone and 
      the cytokine transformation growth factor (TGF)-1beta but smaller tumour necrosis 
      factor (TNF)-alpha levels. Tianeptine treatment of OB rats significantly 
      inhibited peridodontal bone loss, normalized behavioural responses, enhanced 
      TGF-1beta levels, and abolished TNF-alpha decrease, but did not attenuate the 
      increased corticosterone response and the decreased hippocampal GR expression. 
      CONCLUSIONS: These experimental results are consistent with an emerging 
      literature showing that life stress, anxiety, depression, pathological grief, and 
      poor coping behaviour may dysregulate regulatory mechanisms within the brain 
      involved in immune regulation, and thereby alter immune responses and influence 
      the susceptibility/resistance to inflammatory disorders.
FAU - Breivik, Torbjorn
AU  - Breivik T
AD  - Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, 
      Norway. tbreivik@odont.uio.no
FAU - Gundersen, Yngvar
AU  - Gundersen Y
FAU - Myhrer, Trond
AU  - Myhrer T
FAU - Fonnum, Frode
AU  - Fonnum F
FAU - Osmundsen, Harald
AU  - Osmundsen H
FAU - Murison, Robert
AU  - Murison R
FAU - Gjermo, Per
AU  - Gjermo P
FAU - von Horsten, Stephan
AU  - von Horsten S
FAU - Opstad, Per Kristian
AU  - Opstad PK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Periodontol
JT  - Journal of clinical periodontology
JID - 0425123
RN  - 0 (Antidepressive Agents)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Thiazepines)
RN  - 0T493YFU8O (tianeptine)
SB  - IM
MH  - Alveolar Bone Loss/drug therapy/etiology
MH  - Analysis of Variance
MH  - Animals
MH  - Antidepressive Agents/*therapeutic use
MH  - Depression/*complications/drug therapy
MH  - Disease Models, Animal
MH  - Disease Susceptibility
MH  - Inflammation Mediators/blood
MH  - Ligation
MH  - Lipopolysaccharides/immunology
MH  - Male
MH  - Neurogenic Inflammation/etiology
MH  - Neuroimmunomodulation
MH  - Olfactory Bulb/*physiology/surgery
MH  - Periodontitis/blood/drug therapy/*etiology/immunology
MH  - Rats
MH  - Rats, Wistar
MH  - Statistics, Nonparametric
MH  - Thiazepines/*therapeutic use
EDAT- 2006/07/06 09:00
MHDA- 2006/08/23 09:00
CRDT- 2006/07/06 09:00
PHST- 2006/07/06 09:00 [pubmed]
PHST- 2006/08/23 09:00 [medline]
PHST- 2006/07/06 09:00 [entrez]
AID - CPE935 [pii]
AID - 10.1111/j.1600-051X.2006.00935.x [doi]
PST - ppublish
SO  - J Clin Periodontol. 2006 Jul;33(7):469-77. doi: 10.1111/j.1600-051X.2006.00935.x.