PMID- 16823108
OWN - NLM
STAT- MEDLINE
DCOM- 20061120
LR  - 20181201
IS  - 0959-2989 (Print)
IS  - 0959-2989 (Linking)
VI  - 16
IP  - 4 Suppl
DP  - 2006
TI  - The regulatory role of dendritic cells in the immune tolerance.
PG  - S163-70
AB  - Immune homeostasis is important for the protection of a host from pathogen 
      aggression, as well as for preventing autoimmunity. Dendritic cells (DCs), the 
      most potent antigen presenting cells, are critical in innate, adaptive immunity 
      and in central tolerance. Recently, their involvement in peripheral tolerance has 
      been shown. Whether DCs induce immunity or tolerance depends on their state of 
      maturation. Different subsets of tolerogenic DCs have been identified in vivo, 
      either in physiological, or pathological conditions, such as tumors, or GVHD. 
      Moreover, tolerogenic DCs can be generated in vitro, by using different culture 
      conditions, such as IL-10 or TGF-beta. In our study, we obtained tolerogenic DCs, 
      by culturing them in the presence of human mesenchymal stem cells (MSCs).
FAU - Li, Yin-Ping
AU  - Li YP
AD  - Laboratory of Mechanobiology and Engineering of Cells and Tissues, CNRS UMR 7563, 
      Faculty of Medicine and Unit of Cellular and Tissue Therapy, CHU, Nancy, France.
FAU - Latger-Canard, Veronique
AU  - Latger-Canard V
FAU - Marchal, Luc
AU  - Marchal L
FAU - Li, Na
AU  - Li N
FAU - Ou-Yang, Jing-Ping
AU  - Ou-Yang JP
FAU - Stoltz, Jean-Francois
AU  - Stoltz JF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Biomed Mater Eng
JT  - Bio-medical materials and engineering
JID - 9104021
RN  - 0 (Cytokines)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Cell Transplantation
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*cytology
MH  - Homeostasis
MH  - Humans
MH  - Immune System
MH  - *Immune Tolerance
MH  - Immunosuppressive Agents/pharmacology
MH  - Mesenchymal Stem Cells/*cytology
MH  - Models, Biological
MH  - T-Lymphocytes/metabolism
RF  - 46
EDAT- 2006/07/11 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/07/11 09:00
PHST- 2006/07/11 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/07/11 09:00 [entrez]
PST - ppublish
SO  - Biomed Mater Eng. 2006;16(4 Suppl):S163-70.