PMID- 16823176
OWN - NLM
STAT- MEDLINE
DCOM- 20060912
LR  - 20191110
IS  - 1570-5870 (Print)
IS  - 1875-8606 (Electronic)
IS  - 1570-5870 (Linking)
VI  - 28
IP  - 3
DP  - 2006
TI  - Molecular cytogenetics: genomic imbalances in colorectal cancer and their 
      clinical impact.
PG  - 71-84
AB  - Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The 
      application of fluorescence in situ hybridization (FISH) based techniques such as 
      comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed 
      that colorectal carcinomas are characterized by a specific pattern of chromosomal 
      imbalances which sequentially accumulate during cancer progression. This review 
      aims to summarize molecular cytogenetic studies, provides a background on the 
      functional relevance of chromosomal aberrations for colorectal cancer progression 
      and discusses their potential clinical impact.
FAU - Grade, Marian
AU  - Grade M
AD  - Department of General Surgery, University Medical Center Gottingen, Germany.
FAU - Becker, Heinz
AU  - Becker H
FAU - Liersch, Torsten
AU  - Liersch T
FAU - Ried, Thomas
AU  - Ried T
FAU - Ghadimi, B Michael
AU  - Ghadimi BM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Cell Oncol
JT  - Cellular oncology : the official journal of the International Society for 
      Cellular Oncology
JID - 101219418
SB  - IM
MH  - *Chromosome Aberrations
MH  - Colorectal Neoplasms/diagnosis/*genetics/pathology
MH  - Cytogenetic Analysis/*methods
MH  - Disease Progression
MH  - Genome, Human/genetics
MH  - Humans
MH  - Models, Biological
MH  - Nucleic Acid Hybridization/methods
MH  - Spectral Karyotyping/methods
PMC - PMC4615150
EDAT- 2006/07/11 09:00
MHDA- 2006/09/13 09:00
PMCR- 2006/07/05
CRDT- 2006/07/11 09:00
PHST- 2006/07/11 09:00 [pubmed]
PHST- 2006/09/13 09:00 [medline]
PHST- 2006/07/11 09:00 [entrez]
PHST- 2006/07/05 00:00 [pmc-release]
AID - 173815 [pii]
AID - 10.1155/2006/173815 [doi]
PST - ppublish
SO  - Cell Oncol. 2006;28(3):71-84. doi: 10.1155/2006/173815.