PMID- 16823363
OWN - NLM
STAT- MEDLINE
DCOM- 20061201
LR  - 20171116
IS  - 0022-4707 (Print)
IS  - 0022-4707 (Linking)
VI  - 46
IP  - 2
DP  - 2006 Jun
TI  - Effect of a periodized exercise training and active recovery program on antitumor 
      activity and development of dendritic cells.
PG  - 307-14
AB  - AIM: Dendritic cells (DCs) are potent antigen-presenting cells that promote 
      antitumor immunity in vivo when pulsed with tumor antigen. No studies have 
      indicated that exercise training affects DC function. The purpose of this study 
      was to investigate the effect of a 5-week periodized exercise training and active 
      recovery program on the development of DCs, and to test their effect on the 
      antitumor immunity of mononuclear cells (MNC) from blood and spleen against human 
      leukemic U937 and murine lymphoma Yac-1 cells, respectively. METHODS: Male Fisher 
      344 rats were divided into 2 groups: exercise and non-exercise group. The 
      training protocol consisted of running on a motor-driven treadmill 6 days a week 
      for consecutive 5 weeks, during which the running time, treadmill speed, and 
      incline gradient were increased weekly. Active recovery parameters were set at 
      30% of the intensity of the previous day. RESULTS: DC numbers increased 
      significantly (P<0.05) in the exercise group compared to controls, but there were 
      no significant changes in the expression of surface antigens CD80 and CD86. In 
      exercise group MNC-conditioned medium (CM) prepared with 50 microg/mL 
      phytohemagglutinin (PHA) significantly inhibited proliferation of U937 cells, and 
      splenocyte-CM with PHA at 20 and 40 microg/mL significantly inhibited 
      proliferation of YAC-1 cells greater than control group. CONCLUSIONS: The 5-week 
      periodized exercise training with active recovery promotes the number of DCs and 
      enhances the activity of DCs against tumor cells.
FAU - Liao, H F
AU  - Liao HF
AD  - Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.
FAU - Chiang, L M
AU  - Chiang LM
FAU - Yen, C C
AU  - Yen CC
FAU - Chen, Y Y
AU  - Chen YY
FAU - Zhuang, R R
AU  - Zhuang RR
FAU - Lai, L Y
AU  - Lai LY
FAU - Chiang, J
AU  - Chiang J
FAU - Chen, Y J
AU  - Chen YJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - J Sports Med Phys Fitness
JT  - The Journal of sports medicine and physical fitness
JID - 0376337
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-2 Antigen)
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Phytohemagglutinins)
SB  - IM
MH  - Animals
MH  - B7-1 Antigen/analysis
MH  - B7-2 Antigen/analysis
MH  - Blood
MH  - Cell Count
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Culture Media, Conditioned
MH  - Dendritic Cells/*immunology
MH  - *Exercise Therapy
MH  - Humans
MH  - Leukemia/*immunology/pathology
MH  - Leukocytes, Mononuclear/immunology
MH  - Lymphoma/*immunology/pathology
MH  - Male
MH  - Mice
MH  - Phytohemagglutinins/pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Running/physiology
MH  - Spleen/immunology/pathology
MH  - Tumor Cells, Cultured
MH  - U937 Cells
EDAT- 2006/07/11 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/07/11 09:00
PHST- 2006/07/11 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/07/11 09:00 [entrez]
PST - ppublish
SO  - J Sports Med Phys Fitness. 2006 Jun;46(2):307-14.