PMID- 16823800
OWN - NLM
STAT- MEDLINE
DCOM- 20061018
LR  - 20240312
IS  - 1552-4841 (Print)
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Linking)
VI  - 141B
IP  - 6
DP  - 2006 Sep 5
TI  - An association study of the brain-derived neurotrophic factor Val66Met 
      polymorphism and amphetamine response.
PG  - 576-83
AB  - Although genetic factors are known to be important in addiction, no candidate 
      genes have yet been consistently linked to drug use or abuse. Brain-derived 
      neurotrophic factor (BDNF), which has been implicated in the behavioral response 
      to psychomotor stimulants and potentiates neurotransmitters that are strongly 
      linked to addiction, is a logical candidate gene to study. Using a drug challenge 
      approach, we tested for association between BDNF G196A (val66met) genotype and 
      subjective responses to amphetamine (AMPH). Healthy volunteers participated in a 
      double blind, crossover design in which they received placebo, 10 mg, and 20 mg 
      oral d-amphetamine in random order. Subjective and physical responses to 
      ingestion of AMPH were measured at 30-min intervals after drug ingestion. Each 
      subject was genotyped for the BDNF G196A polymorphism and grouped and analyzed 
      accordingly. The effects of AMPH on ratings of arousal, energy, and heart rate 
      were compared in subjects with the val/val genotype (N = 67) and the subjects 
      with either the val/met or met/met genotypes (N = 32). AMPH produced less 
      pronounced self-ratings of arousal and energy, yet higher increases in heart 
      rate, in the val/met and met/met compared to the val/val group. These results 
      suggest that BDNF is related to the subjective and physical response to low doses 
      of AMPH.
FAU - Flanagin, Brody A
AU  - Flanagin BA
AD  - Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, 
      USA.
FAU - Cook, Edwin H Jr
AU  - Cook EH Jr
FAU - de Wit, Harriet
AU  - de Wit H
LA  - eng
GR  - M01 RR000055-390757/RR/NCRR NIH HHS/United States
GR  - DA02812/DA/NIDA NIH HHS/United States
GR  - M01 RR000055/RR/NCRR NIH HHS/United States
GR  - R01 DA002812-25/DA/NIDA NIH HHS/United States
GR  - R01 DA002812/DA/NIDA NIH HHS/United States
GR  - M01RR00055/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Amphetamines)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Amphetamines/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/chemistry/*genetics
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Methionine/*genetics
MH  - Valine/*genetics
PMC - PMC2556402
MID - NIHMS68240
EDAT- 2006/07/11 09:00
MHDA- 2006/10/19 09:00
PMCR- 2008/09/30
CRDT- 2006/07/11 09:00
PHST- 2006/07/11 09:00 [pubmed]
PHST- 2006/10/19 09:00 [medline]
PHST- 2006/07/11 09:00 [entrez]
PHST- 2008/09/30 00:00 [pmc-release]
AID - 10.1002/ajmg.b.30327 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2006 Sep 5;141B(6):576-83. doi: 
      10.1002/ajmg.b.30327.