PMID- 16825687
OWN - NLM
STAT- MEDLINE
DCOM- 20060822
LR  - 20230318
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 84
IP  - 1
DP  - 2006 Jul
TI  - Dietary glycemic index and liver steatosis.
PG  - 136-42; quiz 268-9
AB  - BACKGROUND: Insulin resistance (IR) and liver steatosis (LS) are interlinked 
      metabolic derangements whose prevalence is rapidly increasing, but the effect of 
      dietary carbohydrate quality on LS is unknown. OBJECTIVE: The objective was to 
      describe the relation of IR and LS to total carbohydrate, total dietary fiber, 
      and the glycemic index (GI) and glycemic load of the diet. DESIGN: The study was 
      a cross-sectional evaluation of 247 apparently healthy subjects who had no 
      evidence of viral, toxic, or autoimmune hepatitis and who were unselected for 
      alcohol intake. The homeostasis model assessment index was used as a surrogate 
      measure of IR, and a liver echography was used as a proxy for LS grading. Dietary 
      data were collected by using 3-d food records. Total carbohydrate intake, total 
      dietary fiber, GI, and glycemic load were calculated by using a semiquantitative 
      food-frequency questionnaire concerning the dietary sources of carbohydrates. 
      RESULTS: The prevalence of high-grade LS (HG-LS) increased significantly across 
      quartiles of dietary GI (P for trend < 0.034): HG-LS in the 4th quartile (high 
      GI) was twice that in the first 3 quartiles (low to medium GIs), whereas no 
      relation was observed with total carbohydrates, total dietary fiber, or glycemic 
      load. In insulin-sensitive subjects (first 3 quartiles of homeostasis model 
      assessment index of IR), the prevalence of HG-LS did not differ significantly 
      between GI groups, but, in insulin-resistant subjects (4th quartile of 
      homeostasis model assessment index of IR), it was twice as high in those with 
      high GI as in those with low to medium GIs (P = 0.005). CONCLUSIONS: High-GI 
      dietary habits are associated with HG-LS, particularly in insulin-resistant 
      subjects. Dietary advice on the quality of carbohydrate sources therefore may be 
      a complementary tool for preventing or treating LS of metabolic origin.
FAU - Valtuena, Silvia
AU  - Valtuena S
AD  - Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy.
FAU - Pellegrini, Nicoletta
AU  - Pellegrini N
FAU - Ardigo, Diego
AU  - Ardigo D
FAU - Del Rio, Daniele
AU  - Del Rio D
FAU - Numeroso, Filippo
AU  - Numeroso F
FAU - Scazzina, Francesca
AU  - Scazzina F
FAU - Monti, Lucilla
AU  - Monti L
FAU - Zavaroni, Ivana
AU  - Zavaroni I
FAU - Brighenti, Furio
AU  - Brighenti F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fiber)
SB  - IM
CIN - Am J Clin Nutr. 2006 Jul;84(1):3-4. PMID: 16825675
MH  - Blood Glucose/metabolism
MH  - Cross-Sectional Studies
MH  - Diet Records
MH  - Dietary Carbohydrates/*administration & dosage/classification
MH  - Dietary Fiber/*administration & dosage/classification
MH  - Fatty Liver/diagnostic imaging/*epidemiology/*pathology
MH  - Female
MH  - *Glycemic Index
MH  - Humans
MH  - *Insulin Resistance/physiology
MH  - Lipid Metabolism/physiology
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Ultrasonography
EDAT- 2006/07/11 09:00
MHDA- 2006/08/23 09:00
CRDT- 2006/07/11 09:00
PHST- 2006/07/11 09:00 [pubmed]
PHST- 2006/08/23 09:00 [medline]
PHST- 2006/07/11 09:00 [entrez]
AID - S0002-9165(23)27782-5 [pii]
AID - 10.1093/ajcn/84.1.136 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2006 Jul;84(1):136-42; quiz 268-9. doi: 10.1093/ajcn/84.1.136.