PMID- 16828599
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20071115
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 98
IP  - 2
DP  - 2006 Jul 15
TI  - Cardiac resynchronization therapy in patients with systolic left ventricular 
      dysfunction and symptoms of mild heart failure secondary to ischemic or 
      nonischemic cardiomyopathy.
PG  - 230-5
AB  - Cardiac resynchronization therapy (CRT) is beneficial in selected patients with 
      moderate to severe heart failure (New York Heart Association [NYHA] classes III 
      to IV). Patients with mildly symptomatic heart failure (NYHA class II) are 
      currently not eligible for CRT and the potential beneficial effects in these 
      patients have not been well studied. Fifty consecutive patients in NYHA class II 
      heart failure and 50 consecutive patients in NYHA classes III to IV (control 
      group) were prospectively included. All patients had left ventricular (LV) 
      ejection fraction<or=35% and QRS duration>120 ms. The effects of CRT in NYHA 
      class II patients were compared with the results obtained in both groups. The 
      severity of baseline LV dyssynchrony (assessed with color-coded tissue Doppler 
      imaging) was comparable between patients in NYHA class II versus those in NYHA 
      classes III to IV (83+/-49 vs 96+/-51 ms, p=NS); resynchronization was achieved 
      in all patients. NYHA class II patients showed a significant improvement in LV 
      ejection fraction (from 25+/-7% to 33+/-10%, p<0.001) and reduction in LV 
      end-systolic volume (from 168+/-55 to 132+/-51 ml, p<0.001) after CRT, similar to 
      patients in NYHA classes III to IV. In addition, only 8% of NYHA class II 
      patients had progression of heart failure symptoms. In conclusion, CRT had 
      comparable effects in patients in NYHA class II and in NYHA classes III to IV 
      heart failure in terms of LV resynchronization, improvement in LV ejection 
      fraction, and LV reverse remodeling.
FAU - Bleeker, Gabe B
AU  - Bleeker GB
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Schalij, Martin J
AU  - Schalij MJ
FAU - Holman, Eduard R
AU  - Holman ER
FAU - Steendijk, Paul
AU  - Steendijk P
FAU - van der Wall, Ernst E
AU  - van der Wall EE
FAU - Bax, Jeroen J
AU  - Bax JJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060519
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Aged
MH  - Cardiac Pacing, Artificial/*methods
MH  - Cardiomyopathies/*complications/physiopathology/therapy
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*etiology/physiopathology/therapy
MH  - Heart Rate/physiology
MH  - Humans
MH  - Male
MH  - Myocardial Contraction/*physiology
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Stroke Volume/physiology
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/complications/physiopathology/*therapy
EDAT- 2006/07/11 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/07/11 09:00
PHST- 2005/11/01 00:00 [received]
PHST- 2006/01/24 00:00 [revised]
PHST- 2006/01/24 00:00 [accepted]
PHST- 2006/07/11 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/07/11 09:00 [entrez]
AID - S0002-9149(06)00672-2 [pii]
AID - 10.1016/j.amjcard.2006.01.080 [doi]
PST - ppublish
SO  - Am J Cardiol. 2006 Jul 15;98(2):230-5. doi: 10.1016/j.amjcard.2006.01.080. Epub 
      2006 May 19.