PMID- 16828856
OWN - NLM
STAT- MEDLINE
DCOM- 20070416
LR  - 20140325
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 86
IP  - 2
DP  - 2007 Feb
TI  - Self-administration of 3alpha-androstanediol increases locomotion and analgesia 
      and decreases aggressive behavior of male hamsters.
PG  - 415-21
AB  - Androgens, such as testosterone (T), can have reinforcing effect, which may be 
      due in part to actions of T's metabolite, 3alpha-androstanediol (3alpha-diol). To 
      investigate rewarding effects of 3alpha-diol, gonadally intact adult male 
      hamsters were given a two-bottle choice test to determine the amount of 
      3alpha-diol that would be self-administered over 4 days of exposure. After 2 days 
      of habituation and 4 days of monitoring of consumption, hamsters were tested in 
      an activity monitor and the open field (locomotion/exploration), paw lick 
      (analgesia) and resident-intruder (aggression) tasks. Hamsters consumed 
      significantly more 3alpha-diol than vehicle in the two-bottle choice test. 
      Hamsters that were allowed to self-administer 3alpha-diol made significantly more 
      beam breaks and total entries in the open field had increased latencies to 
      pawlick, and engaged in significantly fewer attacks, than did hamsters with 
      access to vehicle alone. Hamsters that self-administered 3alpha-diol had higher 
      levels of 3alpha-diol in serum, hippocampus, prefrontal cortex, striatum and 
      midbrain than did hamsters with access to vehicle alone. Together, these data 
      suggest that 3alpha-diol may have rewarding effects.
FAU - Frye, Cheryl A
AU  - Frye CA
AD  - Department of Psychology, The University at Albany-SUNY, 1400 Washington Avenue, 
      Albany, NY 12222, USA. cafrye@albany.edu
FAU - Babson, Alicia
AU  - Babson A
FAU - Walf, Alicia A
AU  - Walf AA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20060710
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 25126-76-5 (Androstane-3,17-diol)
SB  - IM
MH  - Aggression/*drug effects
MH  - *Analgesia
MH  - Androstane-3,17-diol/administration & dosage/pharmacokinetics/*pharmacology
MH  - Animals
MH  - Brain/metabolism
MH  - Cricetinae
MH  - Male
MH  - Mesocricetus
MH  - Motor Activity/*drug effects
MH  - Reward
MH  - Self Administration
EDAT- 2006/07/11 09:00
MHDA- 2007/04/17 09:00
CRDT- 2006/07/11 09:00
PHST- 2006/02/03 00:00 [received]
PHST- 2006/04/20 00:00 [revised]
PHST- 2006/05/30 00:00 [accepted]
PHST- 2006/07/11 09:00 [pubmed]
PHST- 2007/04/17 09:00 [medline]
PHST- 2006/07/11 09:00 [entrez]
AID - S0091-3057(06)00170-5 [pii]
AID - 10.1016/j.pbb.2006.05.025 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2007 Feb;86(2):415-21. doi: 10.1016/j.pbb.2006.05.025. 
      Epub 2006 Jul 10.