PMID- 1682951
OWN - NLM
STAT- MEDLINE
DCOM- 19911126
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 39
IP  - 2
DP  - 1991 Jun
TI  - MDL72222, a serotonin 5-HT3 receptor antagonist, blocks MDMA's ability to 
      establish a conditioned place preference.
PG  - 509-12
AB  - Methylenedioxymethamphetamine (MDMA) has previously been shown to produce a 
      positive conditioned place preference (CPP) among rats. Here the effects of doses 
      of a specific 5-HT3 antagonist, MDL72222, on MDMA's ability to produce a CPP were 
      assessed. A dose of MDL72222 (0.03 mg/kg) blocked the establishment of a MDMA 
      CPP. These results support the suggestions that compounds affecting the 5-HT3 
      receptor may be of particular interest in studying the pharmacology of 
      self-administered drugs.
FAU - Bilsky, E J
AU  - Bilsky EJ
AD  - Department of Psychology, Rensselaer Polytechnic Institute, Troy, NY 12180.
FAU - Reid, L D
AU  - Reid LD
LA  - eng
GR  - DA 04440/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Tropanes)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - O98T3677PA (bemesetron)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/antagonists & inhibitors
MH  - Animals
MH  - Conditioning, Operant/*drug effects
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Serotonin Antagonists/*pharmacology
MH  - Tropanes/*pharmacology
EDAT- 1991/06/01 00:00
MHDA- 1991/06/01 00:01
CRDT- 1991/06/01 00:00
PHST- 1991/06/01 00:00 [pubmed]
PHST- 1991/06/01 00:01 [medline]
PHST- 1991/06/01 00:00 [entrez]
AID - 0091-3057(91)90217-P [pii]
AID - 10.1016/0091-3057(91)90217-p [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1991 Jun;39(2):509-12. doi: 
      10.1016/0091-3057(91)90217-p.