PMID- 16829591
OWN - NLM
STAT- MEDLINE
DCOM- 20061129
LR  - 20240315
IS  - 1040-4651 (Print)
IS  - 1532-298X (Electronic)
IS  - 1040-4651 (Linking)
VI  - 18
IP  - 8
DP  - 2006 Aug
TI  - CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in 
      Arabidopsis.
PG  - 1975-90
AB  - CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) is a negative regulator of 
      photomorphogenesis in Arabidopsis thaliana. COP1 functions as an E3 ubiquitin 
      ligase, targeting select proteins for proteasomal degradation in plants as well 
      as in mammals. Among its substrates is the basic domain/leucine zipper (bZIP) 
      transcription factor ELONGATED HYPOCOTYL5 (HY5), one of the key regulators of 
      photomorphogenesis under all light qualities, including UV-B responses required 
      for tolerance to this environmental threat. Here, we report that, in contrast 
      with the situation in visible light, COP1 is a critical positive regulator of 
      responses to low levels of UV-B. We show that in the cop1-4 mutant, flavonoid 
      accumulation and genome-wide expression changes in response to UV-B are blocked 
      to a large extent. COP1 is required for HY5 gene activation, and both COP1 and 
      HY5 proteins accumulate in the nucleus under supplementary UV-B. SUPPRESSOR OF 
      PHYTOCHROME A-105 family proteins (SPA1 to SPA4) that are required for COP1 
      function in dark and visible light are not essential in the response to UV-B. We 
      conclude that COP1 performs a specific and novel role in the plants' 
      photomorphogenic response to UV-B, coordinating HY5-dependent and -independent 
      pathways, which eventually results in UV-B tolerance.
FAU - Oravecz, Attila
AU  - Oravecz A
AD  - Institute of Biology II/Botany, University of Freiburg, D-79104 Freiburg, 
      Germany.
FAU - Baumann, Alexander
AU  - Baumann A
FAU - Mate, Zoltan
AU  - Mate Z
FAU - Brzezinska, Agnieszka
AU  - Brzezinska A
FAU - Molinier, Jean
AU  - Molinier J
FAU - Oakeley, Edward J
AU  - Oakeley EJ
FAU - Adam, Eva
AU  - Adam E
FAU - Schafer, Eberhard
AU  - Schafer E
FAU - Nagy, Ferenc
AU  - Nagy F
FAU - Ulm, Roman
AU  - Ulm R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060707
PL  - England
TA  - Plant Cell
JT  - The Plant cell
JID - 9208688
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (Flavonoids)
RN  - 0 (HY5 protein, Arabidopsis)
RN  - 0 (Nuclear Proteins)
RN  - EC 2.3.2.27 (AT2G32950 protein, Arabidopsis)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Arabidopsis/*enzymology/genetics/radiation effects
MH  - Arabidopsis Proteins/genetics/metabolism/*physiology
MH  - Basic-Leucine Zipper Transcription Factors/metabolism
MH  - Cell Nucleus/metabolism
MH  - Flavonoids/metabolism
MH  - Gene Expression Regulation, Plant/radiation effects
MH  - Genes, Plant
MH  - Hypocotyl/growth & development/metabolism/radiation effects
MH  - Mutation
MH  - Nuclear Proteins/metabolism
MH  - Transcriptional Activation
MH  - Ubiquitin-Protein Ligases/genetics/metabolism/*physiology
MH  - *Ultraviolet Rays
PMC - PMC1533968
EDAT- 2006/07/11 09:00
MHDA- 2006/12/09 09:00
PMCR- 2007/08/01
CRDT- 2006/07/11 09:00
PHST- 2006/07/11 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/07/11 09:00 [entrez]
PHST- 2007/08/01 00:00 [pmc-release]
AID - tpc.105.040097 [pii]
AID - 040097 [pii]
AID - 10.1105/tpc.105.040097 [doi]
PST - ppublish
SO  - Plant Cell. 2006 Aug;18(8):1975-90. doi: 10.1105/tpc.105.040097. Epub 2006 Jul 7.