PMID- 16829787
OWN - NLM
STAT- MEDLINE
DCOM- 20060823
LR  - 20220310
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 82
IP  - 1 Suppl
DP  - 2006 Jul 15
TI  - A novel pathway of antigen presentation by dendritic and endothelial cells: 
      Implications for allorecognition and infectious diseases.
PG  - S15-8
AB  - Dendritic cells (DCs) are the major antigen presenting cells capable of 
      stimulating T cell responses following either organ transplantation or a viral 
      infection. In the context of allorecognition, T cells can be activated following 
      presentation of alloantigens by donor DCs (direct), as well as by recipient DCs 
      presenting processed donor major histocompatibility complex (MHC) as peptides 
      (indirect). We have recently described another mechanism by which alloreactive T 
      cells are activated. Recipient DCs can acquire donor MHC through cell-to-cell 
      contact and this acquired MHC can stimulate a T cell response (the semidirect 
      pathway). Similarly, during a viral infection, DCs are capable of stimulating T 
      cells directly, as occurs when infected DCs present processed viral antigens, or 
      indirectly by a process known as cross-presentation. Although cross-presentation 
      of exogenous antigen is an important mechanism for controlling infectious 
      diseases, it is possible that peptide:MHC acquisition (the semidirect pathway) 
      may also play a part in immunity against pathogens. In this review, we discuss 
      the possible contributions of the semidirect pathway/MHC transfer in infectious 
      disease.
FAU - Smyth, Lesley Ann
AU  - Smyth LA
AD  - Department of Nephrology and Transplantation, Kings College London, Guy's 
      Hospital, London, United Kingdom.
FAU - Herrera, Osquel Barroso
AU  - Herrera OB
FAU - Golshayan, Dela
AU  - Golshayan D
FAU - Lombardi, Giovanna
AU  - Lombardi G
FAU - Lechler, Robert I
AU  - Lechler RI
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Isoantigens)
SB  - IM
MH  - *Antigen Presentation
MH  - Communicable Diseases/*immunology
MH  - Cross-Priming/*immunology
MH  - Dendritic Cells/*immunology
MH  - Endothelial Cells/*immunology
MH  - Humans
MH  - Isoantigens/immunology
MH  - Lymphocyte Activation
MH  - Major Histocompatibility Complex/immunology
MH  - T-Lymphocytes/immunology
RF  - 40
EDAT- 2006/07/11 09:00
MHDA- 2006/08/24 09:00
CRDT- 2006/07/11 09:00
PHST- 2006/07/11 09:00 [pubmed]
PHST- 2006/08/24 09:00 [medline]
PHST- 2006/07/11 09:00 [entrez]
AID - 00007890-200607151-00006 [pii]
AID - 10.1097/01.tp.0000231347.06149.ca [doi]
PST - ppublish
SO  - Transplantation. 2006 Jul 15;82(1 Suppl):S15-8. doi: 
      10.1097/01.tp.0000231347.06149.ca.