PMID- 16829793
OWN - NLM
STAT- MEDLINE
DCOM- 20060823
LR  - 20220408
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 82
IP  - 1 Suppl
DP  - 2006 Jul 15
TI  - Anti-HLA antibodies can induce endothelial cell survival or proliferation 
      depending on their concentration.
PG  - S33-5
AB  - Patients exhibiting a humoral immune response to the transplanted organ are at 
      increased risk of antibody-mediated rejection and development of transplant 
      vasculopathy. Historically, antibodies were thought to elicit transplant 
      rejection through complement mediated damage of the endothelium of the graft. 
      More recently, studies from our laboratory and others have shown that antibody 
      ligation of class I molecules on the surface of endothelial cells transduces 
      signals resulting in functional changes including expression of cell survival 
      proteins and cell proliferation. The intracellular events initiated by antibody 
      ligation are dependent upon the degree of molecular aggregation and influenced by 
      the concentration of the antibody and level of human leukocyte antigen (HLA) 
      expression. Herein we describe our recent findings on the effect of molecular 
      aggregation on the class I signaling pathway in human endothelial cells.
FAU - Jindra, Peter T
AU  - Jindra PT
AD  - Department of Pathology and Laboratory Medicine, UCLA Immunogenetics Center, 
      David Geffen School of Medicine, University of California, Los Angeles, CA 90095, 
      USA.
FAU - Zhang, Xiaohai
AU  - Zhang X
FAU - Mulder, Arend
AU  - Mulder A
FAU - Claas, Frans
AU  - Claas F
FAU - Veale, Jeffrey
AU  - Veale J
FAU - Jin, Yi-Ping
AU  - Jin YP
FAU - Reed, Elaine F
AU  - Reed EF
LA  - eng
GR  - R01AI42819/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antibodies, Monoclonal/*pharmacology
MH  - Cell Proliferation
MH  - Cell Survival/drug effects/immunology
MH  - Endothelial Cells/cytology/*drug effects/*immunology
MH  - Graft Rejection/immunology
MH  - HLA Antigens/analysis/*immunology
MH  - Humans
EDAT- 2006/07/11 09:00
MHDA- 2006/08/24 09:00
CRDT- 2006/07/11 09:00
PHST- 2006/07/11 09:00 [pubmed]
PHST- 2006/08/24 09:00 [medline]
PHST- 2006/07/11 09:00 [entrez]
AID - 00007890-200607151-00011 [pii]
AID - 10.1097/01.tp.0000231447.34240.3c [doi]
PST - ppublish
SO  - Transplantation. 2006 Jul 15;82(1 Suppl):S33-5. doi: 
      10.1097/01.tp.0000231447.34240.3c.