PMID- 16831305
OWN - NLM
STAT- MEDLINE
DCOM- 20060915
LR  - 20231213
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 19
IP  - 2
DP  - 2006 Apr-Jun
TI  - Inhibition of maturation of human monocyte-derived dendritic cells in a patient 
      with Mycobacterium avium infection.
PG  - 391-7
AB  - Mycobacterium avium complex is a facultative intracellular pathogen that can 
      cause pulmonary disease in immunocompromised individuals. Dendritic cells (DCs) 
      play a central role in protective immunity against mycobacteria. Mycobacterium 
      avium complex infects DCs but does not impair in vitro infected monocytes 
      differentiation into DCs. A 54-year old woman affected by chronic 
      graft-versus-host-disease (cGVHD) was referred to our Division of Dermatology. 
      Immature DCs were generated from her monocytes. One week later she was 
      hospitalized due to a lung infection with Mycobacterium avium complex. 
      Monocyte-derived DCs during Mycobacterium avium infection expressed low levels of 
      CD1a and CD80 as determined by flow cytometry. They also expressed high levels of 
      CD83 and CD86, and when stimulated with LPS for 24 hrs they slightly up-regulated 
      CD83 and did not produce IL12. When monocyte-derived DCs were obtained from the 
      patient after having recovered from the Mycobacterium avium complex infection, 
      they expressed normal levels of CD1a and CD80 and were negative both for CD83 and 
      for CD86. IL12 production in response to LPS was restored. Inhibition of DC 
      maturation by the in vivo infection with Mycobacterium avium may be an 
      immune-evasion mechanism used by the pathogen because incompletely matured DCs 
      may not activate effector T cells efficiently in vivo.
FAU - Di Renzo, M
AU  - Di Renzo M
AD  - Department of Clinical Medicine and Immunological Sciences, Azienda Ospedaliera 
      Universitaria Senese, U.O. di Medicina III, Policlinico Le Scotte, 53100 Siena, 
      Italy. cd28apo@hotmail.com
FAU - Pasqui, A L
AU  - Pasqui AL
FAU - Rubegni, P
AU  - Rubegni P
FAU - D'Ascenzo, G
AU  - D'Ascenzo G
FAU - De Aloe, G
AU  - De Aloe G
FAU - Auteri, A
AU  - Auteri A
FAU - Fimiani, M
AU  - Fimiani M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Glycoproteins)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Antigens, CD/immunology
MH  - Antigens, CD1/immunology
MH  - Cell Differentiation/physiology
MH  - Chronic Disease
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/*physiology
MH  - Female
MH  - Flow Cytometry
MH  - Graft vs Host Disease/immunology
MH  - Humans
MH  - Immunoglobulins/immunology
MH  - Interleukin-12/biosynthesis
MH  - Membrane Glycoproteins/immunology
MH  - Middle Aged
MH  - Monocytes/*physiology
MH  - Mycobacterium avium-intracellulare Infection/*immunology
MH  - Phenotype
MH  - CD83 Antigen
EDAT- 2006/07/13 09:00
MHDA- 2006/09/16 09:00
CRDT- 2006/07/13 09:00
PHST- 2006/07/13 09:00 [pubmed]
PHST- 2006/09/16 09:00 [medline]
PHST- 2006/07/13 09:00 [entrez]
AID - 15 [pii]
AID - 10.1177/039463200601900215 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):391-7. doi: 
      10.1177/039463200601900215.