PMID- 1683236
OWN - NLM
STAT- MEDLINE
DCOM- 19911230
LR  - 20051116
IS  - 0904-1850 (Print)
IS  - 0904-1850 (Linking)
VI  - 13
DP  - 1991 Apr
TI  - Aberrant T cell regulation of IgE production in atopy.
PG  - 27s-30s
AB  - Atopy is associated with elevated serum levels of allergen-specific 
      immunoglobulin E (IgE). IgE production is preferentially induced by the T 
      cell-derived lymphokine interleukin-4 (IL-4) and is suppressed by interferon and 
      prostaglandins, of which interferon-gamma (IFN-gamma) is produced by T cells. We 
      review our studies on the question of whether atopy is associated with CD4+ 
      allergen-specific T cells with an unbalanced lymphokine production. We prepared 
      panels of housedust mite (Dermatophagoides pteronyssinus)-specific T lymphocyte 
      clones (TLC) from atopic and non-atopic individuals and found that TLC from 
      housedust mite-allergic patients produced IL-4 but not IFN-gamma, whereas such 
      TLC from a non-atopic individual produced IFN-gamma and only in some cases small 
      amounts of IL-4. Candida albicans- and tetanus toxoid-specific TLC, established 
      from one of the atopic donors, also produced IFN-gamma without IL-4, suggesting 
      that the atopic state is characterized by a defective accumulation of 
      IL-4-producing CD4+ T lymphocytes into the allergen-specific T cell repertoire.
FAU - Kapsenberg, M L
AU  - Kapsenberg ML
AD  - Laboratory of Cell Biology and Histology, University of Amsterdam, The 
      Netherlands.
FAU - Wierenga, E A
AU  - Wierenga EA
FAU - Bos, J D
AU  - Bos JD
FAU - Jansen, H M
AU  - Jansen HM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Eur Respir J Suppl
JT  - The European respiratory journal. Supplement
JID - 8910681
RN  - 0 (Allergens)
RN  - 0 (Lymphokines)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/*immunology
MH  - Immunoglobulin E/*biosynthesis
MH  - Lymphokines/biosynthesis
MH  - T-Lymphocytes/*immunology
RF  - 19
EDAT- 1991/04/01 00:00
MHDA- 1991/04/01 00:01
CRDT- 1991/04/01 00:00
PHST- 1991/04/01 00:00 [pubmed]
PHST- 1991/04/01 00:01 [medline]
PHST- 1991/04/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J Suppl. 1991 Apr;13:27s-30s.