PMID- 16835249
OWN - NLM
STAT- MEDLINE
DCOM- 20060929
LR  - 20151119
IS  - 1460-2156 (Electronic)
IS  - 0006-8950 (Linking)
VI  - 129
IP  - Pt 8
DP  - 2006 Aug
TI  - Selective COX-2 inhibitor celecoxib prevents experimental autoimmune 
      encephalomyelitis through COX-2-independent pathway.
PG  - 1984-92
AB  - Cyclooxygenase (COX) is a key enzyme of arachidonic acid metabolism and exists as 
      two distinct isoforms. COX-1 is constitutively expressed in most tissues, whereas 
      COX-2 is inducibly expressed at the site of inflammation. Selective inhibitors of 
      COX-2 have been developed and have been used as anti-inflammatory agents. Here, 
      we show that a new-generation COX-2 inhibitor, celecoxib, inhibited experimental 
      autoimmune encephalomyelitis (EAE). Celecoxib, but not other COX-2 inhibitors 
      such as nimesulid, prevented myelin oligodendrocyte glycoprotein (MOG) induced 
      EAE when administrated orally on the day of disease induction. Moreover, 
      celecoxib inhibited EAE in COX-2-deficient mice, indicating that celecoxib 
      inhibited EAE in a COX-2-independent manner. In celecoxib-treated mice, 
      interferon-gamma (IFN-gamma) production from MOG-specific T cells was reduced and 
      MOG-specific IgG1 was elevated compared with vehicle-treated mice. Infiltration 
      of inflammatory cells into the central nervous system and the expression of 
      adhesion molecules, P-selectin and intercellular adhesion molecule-1 (ICAM-1), 
      and a chemokine, monocyte chemoattractant peptide-1 (MCP-1), were inhibited when 
      mice were treated with celecoxib. These results suggest that celecoxib may be 
      useful as a new additional therapeutic agent for multiple sclerosis.
FAU - Miyamoto, Katsuichi
AU  - Miyamoto K
AD  - Department of Immunology, National Institute of Neuroscience, NCNP, Kodaira, 
      Tokyo, Japan.
FAU - Miyake, Sachiko
AU  - Miyake S
FAU - Mizuno, Miho
AU  - Mizuno M
FAU - Oka, Nobuyuki
AU  - Oka N
FAU - Kusunoki, Susumu
AU  - Kusunoki S
FAU - Yamamura, Takashi
AU  - Yamamura T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060710
PL  - England
TA  - Brain
JT  - Brain : a journal of neurology
JID - 0372537
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cyclooxygenase 2 Inhibitors)
RN  - 0 (Mog protein, mouse)
RN  - 0 (Myelin Proteins)
RN  - 0 (Myelin-Associated Glycoprotein)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
RN  - 0 (Pyrazoles)
RN  - 0 (Sulfonamides)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - JCX84Q7J1L (Celecoxib)
SB  - IM
MH  - Animals
MH  - Celecoxib
MH  - Cell Adhesion Molecules/metabolism
MH  - Central Nervous System/immunology/pathology
MH  - Chemokine CCL2/blood
MH  - Cyclooxygenase 2/deficiency/*physiology
MH  - Cyclooxygenase 2 Inhibitors/*therapeutic use
MH  - Encephalomyelitis, Autoimmune, 
      Experimental/enzymology/immunology/pathology/*prevention & control
MH  - Female
MH  - Leukemic Infiltration/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myelin Proteins
MH  - Myelin-Associated Glycoprotein/immunology
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - Pyrazoles/*therapeutic use
MH  - Signal Transduction
MH  - Sulfonamides/*therapeutic use
MH  - Th1 Cells/drug effects/immunology
EDAT- 2006/07/13 09:00
MHDA- 2006/09/30 09:00
CRDT- 2006/07/13 09:00
PHST- 2006/07/13 09:00 [pubmed]
PHST- 2006/09/30 09:00 [medline]
PHST- 2006/07/13 09:00 [entrez]
AID - awl170 [pii]
AID - 10.1093/brain/awl170 [doi]
PST - ppublish
SO  - Brain. 2006 Aug;129(Pt 8):1984-92. doi: 10.1093/brain/awl170. Epub 2006 Jul 10.