PMID- 1683546
OWN - NLM
STAT- MEDLINE
DCOM- 19920108
LR  - 20170214
IS  - 0960-3271 (Print)
IS  - 0960-3271 (Linking)
VI  - 10
IP  - 5
DP  - 1991 Sep
TI  - Influence of simultaneous supplementation of zinc and copper during chelation of 
      lead in rats.
PG  - 331-6
AB  - The influence of zinc and copper supplementation during chelation therapy to 
      reduce zinc and copper imbalance and promote lead elimination from the body, was 
      investigated in rats poisoned with lead. The simultaneous supplementation of zinc 
      and copper increased urinary lead excretion by calcium disodium ethylenediamine 
      tetraacetic acid (CaNa2EDTA) compared to treatment with CaNa2EDTA alone. 
      Combination therapy was effective in potentiating the depletion of blood and 
      renal lead by CaNa2EDTA and meso 2,3-dimercapto succinic acid (DMSA). Combination 
      therapy was also more effective in reducing hepatic lead by CaNa2EDTA and blood 
      lead by 2,3-dimercapto propane sulphonate (DMPS). Zinc and copper supplementation 
      produced a more effective reversal of inhibited blood delta-aminolevulinic acid 
      dehydratase (ALAD) activity, urinary delta-aminolevulinic acid excretion and 
      depleted body zinc and copper status.
FAU - Flora, S J
AU  - Flora SJ
AD  - Division of Pharmacology and Toxicology, Defence Research & Development 
      Establishment, Gwalior, India.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Chelating Agents)
RN  - 0 (Protoporphyrins)
RN  - 15442-64-5 (zinc protoporphyrin)
RN  - 2P299V784P (Lead)
RN  - 789U1901C5 (Copper)
RN  - 88755TAZ87 (Aminolevulinic Acid)
RN  - EC 4.2.1.24 (Porphobilinogen Synthase)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Aminolevulinic Acid/urine
MH  - Animals
MH  - Chelating Agents/therapeutic use
MH  - Chelation Therapy
MH  - Copper/administration & dosage/*pharmacology
MH  - Drug Administration Schedule
MH  - Drug Therapy, Combination
MH  - Lead/*toxicity
MH  - Porphobilinogen Synthase/blood
MH  - Protoporphyrins/blood
MH  - Rats
MH  - Zinc/administration & dosage/*pharmacology
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
AID - 10.1177/096032719101000506 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 1991 Sep;10(5):331-6. doi: 10.1177/096032719101000506.