PMID- 16836071
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20211203
VI  - 20
IP  - 9
DP  - 2006 May
TI  - [Expression of integrin-linked kinase is closely correlated with laryngeal 
      squamous cell carcinomas].
PG  - 393-5
AB  - OBJECTIVE: To study whether Integrin linked kinase (ILK) is involved in the 
      development and progression of laryngeal squamous cell carcinomas (LSCC). METHOD: 
      We examined the expression of ILK in 64 LSCC (LSCC group) and 10 normal laryngeal 
      mucosa (control group) using reverse transcription polymerase chain reaction 
      (RT-PCR) and analyzed the relationship with clinic pathological parameters. 
      RESULT: The expression of ILK mRNA was significantly higher in 64 LSCC tissue (0. 
      644 +/- 0. 098) than in normal laryngeal mucosa tissues (0.032 +/- 0.026, P 
      <0.05). The expression of ILK mRNA in LSCC with the metastasis of lymph nodes (0. 
      867 +/- 0.247) was significantly higher than those without metastasis (0.389 +/- 
      0.199, P <0.05). With the development of clinical T-stages of LSCC, the 
      expression of ILK mRNA in LSCC increases. There was no significant difference 
      between different clinical stage groups (P > 0.05). CONCLUSION: These results 
      suggest that ILK may participate not only in LSCC but also in invasion and 
      metastasis of LSCC. ILK might be a novel molecular marker for prognosticating 
      metastases and prognosis of LSCC.
FAU - Wu, Changzhu
AU  - Wu C
AD  - Department of Otorhinolaryngology, the First Affiliated Hospital of China Medical 
      University, Beijing, China. wuchangzhu@sina.com
FAU - Zhai, Ning
AU  - Zhai N
FAU - Guan, Chao
AU  - Guan C
FAU - Ji, Wenyu
AU  - Ji W
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.1.- (integrin-linked kinase)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/pathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Protein Serine-Threonine Kinases/genetics/*metabolism
MH  - RNA, Messenger/genetics
EDAT- 2006/07/14 09:00
MHDA- 2011/04/16 06:00
CRDT- 2006/07/14 09:00
PHST- 2006/07/14 09:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
PHST- 2006/07/14 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 May;20(9):393-5.