PMID- 16837499
OWN - NLM
STAT- MEDLINE
DCOM- 20070206
LR  - 20201209
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 28
IP  - 5
DP  - 2006 Nov
TI  - Mechanical ventilation affects alveolar fibrinolysis in LPS-induced lung injury.
PG  - 992-8
AB  - The aim of the present study was to determine the effects of mechanical 
      ventilation on alveolar fibrin turnover in lipopolysaccharide (LPS)-induced lung 
      injury. In a randomised controlled trial, Sprague-Dawley rats (n = 61) were 
      allocated to three ventilation groups after intratracheal LPS (Salmonella 
      enteritidis) instillations. Group I animals were subjected to 16 cmH(2)O positive 
      inspiratory pressure (PIP) and 5 cmH(2)O positive end-expiratory pressure (PEEP); 
      group II animals to 26 cmH(2)O PIP and 5 cmH(2)O PEEP; and group III animals to 
      35 cmH(2)O PIP and 5 cmH(2)O PEEP. Control rats (not mechanically ventilated) 
      received LPS. Healthy rats served as a reference group. Levels of 
      thrombin-antithrombin complex (TATc), D-dimer, plasminogen activator inhibitor 
      (PAI) activity and PAI-1 antigen in bronchoalveolar lavage fluid were measured. 
      LPS-induced lung injury increased TATc, D-dimer and PAI activity and PAI-1 
      antigen levels versus healthy animals. High pressure-amplitude ventilation 
      increased TATc concentrations. D-dimer concentrations were not significantly 
      raised. Instead, PAI activity increased with the amplitude of the pressure, from 
      0.7 U.mL(-1) in group I to 3.4 U.mL(-1) in group II and 5.0 U.mL(-1) in group 
      III. There was no change in PAI-1 antigen levels. In conclusion, mechanical 
      ventilation creates an alveolar/pulmonary anti-fibrinolytic milieu in 
      endotoxin-induced lung injury which, at least in part, might be due to an 
      increase in plasminogen activator inhibitor activity.
FAU - Dahlem, P
AU  - Dahlem P
AD  - Dept of Anaesthesiology, Erasmus MC-Faculty Rotterdam, Rotterdam, Amsterdam. 
      PDahlem@hotmail.com
FAU - Bos, A P
AU  - Bos AP
FAU - Haitsma, J J
AU  - Haitsma JJ
FAU - Schultz, M J
AU  - Schultz MJ
FAU - Wolthuis, E K
AU  - Wolthuis EK
FAU - Meijers, J C M
AU  - Meijers JC
FAU - Lachmann, B
AU  - Lachmann B
LA  - eng
PT  - Journal Article
DEP - 20060712
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Disease Models, Animal
MH  - Fibrinolysis/*physiology
MH  - Lipopolysaccharides/*adverse effects
MH  - Male
MH  - Pulmonary Alveoli/*injuries/metabolism/*microbiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Respiration, Artificial/*adverse effects
MH  - Respiratory Distress Syndrome/physiopathology
MH  - Salmonella enteritidis/*pathogenicity
EDAT- 2006/07/14 09:00
MHDA- 2007/02/07 09:00
CRDT- 2006/07/14 09:00
PHST- 2006/07/14 09:00 [pubmed]
PHST- 2007/02/07 09:00 [medline]
PHST- 2006/07/14 09:00 [entrez]
AID - 09031936.06.00133104 [pii]
AID - 10.1183/09031936.06.00133104 [doi]
PST - ppublish
SO  - Eur Respir J. 2006 Nov;28(5):992-8. doi: 10.1183/09031936.06.00133104. Epub 2006 
      Jul 12.