PMID- 16839856
OWN - NLM
STAT- MEDLINE
DCOM- 20061114
LR  - 20131121
IS  - 0741-8329 (Print)
IS  - 0741-8329 (Linking)
VI  - 38
IP  - 2
DP  - 2006 Feb
TI  - Reversal learning after prenatal or early postnatal alcohol exposure in juvenile 
      and adult rats.
PG  - 99-110
AB  - Learning tasks that require the reversal of a previously learned contingency are 
      disrupted in animals and humans exposed to alcohol during the perinatal period. 
      The current experiments examined how varying the time of alcohol exposure and the 
      age at which subjects were tested would affect the expression of reversal 
      deficits in a T-maze task. Groups of rats were exposed to alcohol from 
      gestational day (GD) 8 to GD20 or from postnatal day (PN) 4 to PN9, and then 
      tested in a spatial reversal task at either PN28 or PN63. Results indicate that 
      exposure to alcohol during the prenatal period did not lead to substantial 
      dose-dependent reversal learning deficits in males or females at either age 
      tested. However, exposure to alcohol during the early postnatal period, a period 
      that corresponds to the third trimester in human neural development, selectively 
      disrupted reversal learning performance in male rats at PN28 but not PN63. 
      Statistically significant sex differences were seen when subjects were tested at 
      PN63. These results demonstrate how the timing of alcohol exposure leads to 
      variability in the age-dependent expression of learning deficits associated with 
      fetal alcohol effects.
FAU - O'Leary-Moore, Shonagh K
AU  - O'Leary-Moore SK
AD  - Department of Obstetrics & Gynecology, C.S. Mott Center for Human Growth & 
      Development, 275 East Hancock, Detroit, MI 48201, USA. soleary@wayne.edu
FAU - McMechan, Andrew P
AU  - McMechan AP
FAU - Mathison, Shannon N
AU  - Mathison SN
FAU - Berman, Robert F
AU  - Berman RF
FAU - Hannigan, John H
AU  - Hannigan JH
LA  - eng
GR  - R01-AA12015/AA/NIAAA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Aging
MH  - Animals
MH  - *Animals, Newborn
MH  - Ethanol/*administration & dosage/blood
MH  - Female
MH  - Gestational Age
MH  - Male
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reversal Learning/*drug effects
MH  - Sex Characteristics
EDAT- 2006/07/15 09:00
MHDA- 2006/11/15 09:00
CRDT- 2006/07/15 09:00
PHST- 2005/12/19 00:00 [received]
PHST- 2006/05/18 00:00 [revised]
PHST- 2006/05/19 00:00 [accepted]
PHST- 2006/07/15 09:00 [pubmed]
PHST- 2006/11/15 09:00 [medline]
PHST- 2006/07/15 09:00 [entrez]
AID - S0741-8329(06)00094-2 [pii]
AID - 10.1016/j.alcohol.2006.05.005 [doi]
PST - ppublish
SO  - Alcohol. 2006 Feb;38(2):99-110. doi: 10.1016/j.alcohol.2006.05.005.