PMID- 16840501
OWN - NLM
STAT- MEDLINE
DCOM- 20070130
LR  - 20231105
IS  - 0003-4967 (Print)
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 66
IP  - 1
DP  - 2007 Jan
TI  - Polyarticular psoriatic arthritis is more like oligoarticular psoriatic 
      arthritis, than rheumatoid arthritis.
PG  - 113-7
AB  - BACKGROUND: and objective: Since the original description of psoriatic arthritis 
      (PsA) subgroups by Moll and Wright, there has been some discrepancy in the 
      precise prevalence of the different subgroups and in particular the proportion of 
      patients with polyarthritis. The higher prevalence of the polyarthritis subgroup 
      may be due to the inclusion of patients with seronegative rheumatoid arthritis 
      with coincidental psoriasis. The classification of psoriatic arthritis (CASPAR) 
      study database provided an opportunity to examine this question. METHODS: The 
      CASPAR study collected clinical, radiological and laboratory data on 588 patients 
      with physician-diagnosed PsA and 525 controls with other inflammatory arthritis, 
      70% of whom had rheumatoid arthritis. Patients with PsA were divided into two 
      groups: polyarthritis and non-polyarthritis (which included the Moll and Wright 
      subgroups of spinal disease, distal interphalangeal predominant and arthritis 
      mutilans) and were compared with patients with rheumatoid arthritis. Comparisons 
      were made between all three groups and, if a significant difference occurred, 
      between the two groups with PsA. RESULTS: The three groups differed significantly 
      with regard to all clinical and laboratory variables except duration of disease. 
      Significant differences were also found between the two groups of PsA in terms of 
      age, sex, total number of involved joints, disability score and symmetry. 
      However, no differences were found between the groups of patients with PsA in 
      terms of seropositivity for rheumatoid factor and antibodies to cyclic 
      citrullinated peptide, enthesitis, and spinal pain and stiffness. Further, 
      dactylitis was commonly seen in patients with PsA (57% in the polyarticular group 
      and 45% in non-polyarticular group), and uncommonly found in patients with 
      rheumatoid arthritis (5%). With the exception of entheseal changes, 
      syndesmophytes and osteolysis, typical radiological features of PsA could not be 
      used to distinguish between the PsA subgroups. CONCLUSIONS: The evidence suggests 
      that the changing prevalence of the polyarticular subgroup of PsA is not because 
      doctors include patients with seronegative rheumatoid arthritis with coincidental 
      psoriasis.
FAU - Helliwell, P S
AU  - Helliwell PS
AD  - Academic Unit of Musculoskeletal and Rehabilitation Medicine, University of 
      Leeds, 36 Clarendon Road, Leeds LS2 9NZ, UK. p.helliwell@leeds.ac.uk
FAU - Porter, G
AU  - Porter G
FAU - Taylor, W J
AU  - Taylor WJ
CN  - CASPAR Study Group
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060713
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
SB  - IM
MH  - Arthritis/diagnostic imaging/immunology/pathology
MH  - Arthritis, Psoriatic/diagnostic imaging/immunology/*pathology
MH  - Arthritis, Rheumatoid/diagnostic imaging/immunology/*pathology
MH  - Data Collection
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Psoriasis/diagnostic imaging/immunology/pathology
MH  - Radiography
PMC - PMC1798397
COIS- Competing interests: None.
EDAT- 2006/07/15 09:00
MHDA- 2007/01/31 09:00
PMCR- 2010/01/01
CRDT- 2006/07/15 09:00
PHST- 2006/07/15 09:00 [pubmed]
PHST- 2007/01/31 09:00 [medline]
PHST- 2006/07/15 09:00 [entrez]
PHST- 2010/01/01 00:00 [pmc-release]
AID - ard.2006.054288 [pii]
AID - ar54288 [pii]
AID - 10.1136/ard.2006.054288 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2007 Jan;66(1):113-7. doi: 10.1136/ard.2006.054288. Epub 2006 Jul 
      13.