PMID- 16840580
OWN - NLM
STAT- MEDLINE
DCOM- 20070104
LR  - 20130926
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 101
IP  - 6
DP  - 2006 Dec
TI  - Attenuated gastric distress but no benefit to performance with adaptation to 
      octanoate-rich esterified oils in well-trained male cyclists.
PG  - 1733-43
AB  - We investigated the effects of modifying a normal dietary fatty acid composition 
      and ingestion of high-fat exercise supplements on gastrointestinal distress, 
      substrate oxidation, and endurance cycling performance. Nine well-trained male 
      cyclists completed a randomized triple-crossover comprising a 2-wk diet high in 
      octanoate-rich esterified oil (MCFA) or twice long-chain fatty acids (LCFA). 
      Following the diets, participants performed 3-h of cycling at 50% of peak power 
      followed by 10 maximal sprints while ingesting either 1) a carbohydrate 
      (CHO)+MCFA-rich oil emulsion after the 2-wk MCFA-rich dietary condition (MC-MC, 
      Intervention) and 2) after one of the LCFA-rich dietary conditions (LC-MC, 
      Placebo) or 3) CHO only following a LCFA-rich diet (LC-CHO, Control). During the 
      3-h ride MCFA-adaptation decreased octanoic-acid oxidation by 24% (90% confidence 
      interval: 14-34%). The CHO+MCFA-rich oil emulsion reduced endogenous fat 
      oxidation by 61% (33-89%) and 110% (89-131%) in the MC-MC and LC-MC conditions, 
      respectively, and MCFA-adaptation reduced endogenous-carbohydrate oxidation by 
      10% (-3-23%). MCFA-adaptation attenuated gastrointestinal distress and nausea 
      during the sprints, but the effect of the oil emulsion was to lower sprint power 
      by 10.9% (7.7-14.1%) in the LC-MC condition and by 7.1% (5.7-8.5%) in the MC-MC 
      condition, relative to the LC-CHO control; every one unit increase in nausea 
      decreased mean power by 6.0 W (3.2-8.8 W). We conclude that despite some 
      attenuation of endogenous-carbohydrate oxidation and gastric distress following 
      adaptation to a MCFA-rich diet, repeat sprint performance was substantially 
      impaired in response to the ingestion of a CHO+MCFA-rich oil emulsion.
FAU - Thorburn, Megan S
AU  - Thorburn MS
AD  - Institute of Food, Nutrition, and Human Health, Massey University, PO Box 756, 
      Wellington, New Zealand.
FAU - Vistisen, Bodil
AU  - Vistisen B
FAU - Thorp, Rhys M
AU  - Thorp RM
FAU - Rockell, Mike J
AU  - Rockell MJ
FAU - Jeukendrup, Asker E
AU  - Jeukendrup AE
FAU - Xu, Xuebing
AU  - Xu X
FAU - Rowlands, David S
AU  - Rowlands DS
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20060713
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids)
SB  - IM
MH  - Adaptation, Physiological/drug effects
MH  - Administration, Oral
MH  - Adult
MH  - *Bicycling
MH  - Cross-Over Studies
MH  - Dietary Fats/*administration & dosage
MH  - Double-Blind Method
MH  - Fatty Acids/*administration & dosage
MH  - Gastrointestinal Diseases/*physiopathology/*prevention & control
MH  - Humans
MH  - Male
MH  - Physical Endurance/*drug effects
MH  - *Physical Fitness
MH  - Treatment Outcome
EDAT- 2006/07/15 09:00
MHDA- 2007/01/05 09:00
CRDT- 2006/07/15 09:00
PHST- 2006/07/15 09:00 [pubmed]
PHST- 2007/01/05 09:00 [medline]
PHST- 2006/07/15 09:00 [entrez]
AID - 00393.2006 [pii]
AID - 10.1152/japplphysiol.00393.2006 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2006 Dec;101(6):1733-43. doi: 
      10.1152/japplphysiol.00393.2006. Epub 2006 Jul 13.