PMID- 1684084
OWN - NLM
STAT- MEDLINE
DCOM- 19920110
LR  - 20200824
IS  - 0002-9297 (Print)
IS  - 1537-6605 (Electronic)
IS  - 0002-9297 (Linking)
VI  - 49
IP  - 6
DP  - 1991 Dec
TI  - A radiation hybrid map of the proximal long arm of human chromosome 11 containing 
      the multiple endocrine neoplasia type 1 (MEN-1) and bcl-1 disease loci.
PG  - 1189-96
AB  - We describe a high-resolution radiation hybrid map of the proximal long arm of 
      human chromosome 11 containing the bcl-1 and multiple endocrine neoplasia type 1 
      (MEN-1) disease gene loci. We used X-ray irradiation and cell fusion to generate 
      a panel of 102 hamster-human somatic cell hybrids containing fragments of human 
      chromosome 11. Sixteen human loci in the 11q12-13 region were mapped by 
      statistical analysis of the cosegregation of markers in these radiation hybrids. 
      The most likely order for these loci is C1NH-OSBP-(CD5/CD20)-PGA-FTH1-COX8-PYGM 
      -SEA-KRN1-(MTC/P11EH/HSTF1/INT2)-GST3- PPP1A. Our localization of the human 
      protooncogene SEA between PYGM and INT2, two markers that flank MEN-1, suggests 
      SEA as a potential candidate for the MEN-1 locus. We map two mitogenic fibroblast 
      growth factor genes, HSTF1 and INT2, close to bcl-1, a mapping that is consistent 
      with previously published data. Our map places the human leukocyte antigen genes 
      CD5 and CD20 far from the bcl-1 locus, indicating that CD5 and CD20 expression is 
      unlikely to be altered by bcl-1 rearrangements. PPP1A, which has been postulated 
      as a MEN-1 candidate tumor suppressor gene, and GST3, a gene transcriptionally 
      active in many human cancers, both map distal to the bcl-1 translocation cluster 
      and the region containing MEN-1, and therefore are unlikely to be directly 
      involved in bcl-1 or MEN-1.
FAU - Richard, C W 3rd
AU  - Richard CW 3rd
AD  - Department of Psychiatry, University of California, San Francisco 94143-0554.
FAU - Withers, D A
AU  - Withers DA
FAU - Meeker, T C
AU  - Meeker TC
FAU - Maurer, S
AU  - Maurer S
FAU - Evans, G A
AU  - Evans GA
FAU - Myers, R M
AU  - Myers RM
FAU - Cox, D R
AU  - Cox DR
LA  - eng
GR  - MH00802/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
RN  - 0 (Genetic Markers)
SB  - IM
GS  - C1NH
GS  - CD20
GS  - CD5
GS  - COX8
GS  - FTH1
GS  - GST3
GS  - HSTF1
GS  - INT2
GS  - KRN1
GS  - OSBP
GS  - PGA
GS  - PPP1A
GS  - PYGM
GS  - SEA
GS  - bcl-1 MTC
GS  - bcl-1 P11EH
MH  - Animals
MH  - Base Sequence
MH  - Cell Line
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11/radiation effects
MH  - Cricetinae
MH  - Cricetulus
MH  - *Genetic Markers
MH  - Humans
MH  - Hybrid Cells/radiation effects
MH  - Leukemia/*genetics
MH  - Lymphoma/*genetics
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia/*genetics
MH  - *Proto-Oncogenes
MH  - Recombination, Genetic
MH  - Translocation, Genetic
PMC - PMC1686449
EDAT- 1991/12/01 00:00
MHDA- 1991/12/01 00:01
PMCR- 1992/06/01
CRDT- 1991/12/01 00:00
PHST- 1991/12/01 00:00 [pubmed]
PHST- 1991/12/01 00:01 [medline]
PHST- 1991/12/01 00:00 [entrez]
PHST- 1992/06/01 00:00 [pmc-release]
PST - ppublish
SO  - Am J Hum Genet. 1991 Dec;49(6):1189-96.