PMID- 16841248
OWN - NLM
STAT- MEDLINE
DCOM- 20060926
LR  - 20191210
IS  - 0966-0844 (Print)
IS  - 0966-0844 (Linking)
VI  - 19
IP  - 4
DP  - 2006 Aug
TI  - DMPS and N-acetylcysteine induced renal toxicity in mice exposed to mercury.
PG  - 389-98
AB  - Acute effects of mercuric chloride (HgCl2) were evaluated on mice. Mice received 
      a single dose of HgCl2 (4.6 mg/kg, subcutaneously) for three consecutive days. 
      Thirty minutes after the last injection with HgCl2, mice received one single 
      injection of 2,3-dimercapto-1-propanesulfonic acid (DMPS) or N-acetylcysteine 
      (NAC) or diphenyl diselenide (PhSe)2. DMPS, NAC and (PhSe)2 were utilized as 
      therapy against mercury exposure. At 24 h after the last HgCl2 injection, blood, 
      liver and kidney samples were collected. delta-Aminolevulinate dehydratase 
      (delta-ALA-D) and Na+, K- (+) ATPase activities, thiobarbituric acid-reactive 
      substances (TBARS), non-protein thiols (NPSH) and ascorbic acid concentrations 
      were evaluated. Plasma aspartate (AST) and alanine (ALT) aminotransferase 
      activities, as well as urea and creatinine levels were determined. The group of 
      mice exposed to Hg + (PhSe)2 presented 100% of lethality. Exposure with HgCl2 
      caused a decrease on the body weight gain and treatments did not modify this 
      parameter. delta-ALA-D, AST and ALT activities, TBARS, ascorbic acid levels and 
      NPSH (hepatic and erythrocytic) levels were not changed after HgCl2 exposure. 
      HgCl2 caused an increase in renal NPSH content and therapies did not modify these 
      levels. Mice treated with (PhSe)2, Hg + NAC and Hg + DMPS presented a reduction 
      in plasma NPSH levels. Creatinine and urea levels were increased in mice exposed 
      to Hg + NAC, while Hg + DMPS group presented an increase only in urea level. Na+, 
      K- (+) ATPase activity was inhibited in mice exposed to Hg + DMPS and Hg + NAC. 
      In conclusion, therapies with (PhSe)2, DMPS and NAC following mercury exposure 
      must be better studied because the formation of more toxic complexes with 
      mercury, which can mainly damage renal tissue.
FAU - Brandao, Ricardo
AU  - Brandao R
AD  - Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade 
      Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil.
FAU - Santos, Francielli W
AU  - Santos FW
FAU - Zeni, Gilson
AU  - Zeni G
FAU - Rocha, Joao B T
AU  - Rocha JB
FAU - Nogueira, Cristina W
AU  - Nogueira CW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biometals
JT  - Biometals : an international journal on the role of metal ions in biology, 
      biochemistry, and medicine
JID - 9208478
RN  - 0 (Antidotes)
RN  - 0 (Benzene Derivatives)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Organoselenium Compounds)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 1666-13-3 (diphenyldiselenide)
RN  - 4076-02-2 (Unithiol)
RN  - 53GH7MZT1R (Mercuric Chloride)
RN  - 8W8T17847W (Urea)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - EC 4.2.1.24 (Porphobilinogen Synthase)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
RN  - FXS1BY2PGL (Mercury)
RN  - MU72812GK0 (Creatine)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/*pharmacology
MH  - Alanine Transaminase/metabolism
MH  - Animals
MH  - Antidotes/pharmacology
MH  - Aspartate Aminotransferases/metabolism
MH  - Benzene Derivatives/pharmacology
MH  - Body Weight/drug effects
MH  - Creatine/metabolism
MH  - Enzyme Activation/drug effects
MH  - Free Radical Scavengers/pharmacology
MH  - Kidney/*drug effects/metabolism/pathology
MH  - Lipid Metabolism/drug effects
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Mercuric Chloride/toxicity
MH  - Mercury/*toxicity
MH  - Mercury Poisoning/metabolism/mortality/prevention & control
MH  - Mice
MH  - Organoselenium Compounds/pharmacology
MH  - Porphobilinogen Synthase/metabolism
MH  - Sodium-Potassium-Exchanging ATPase/metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Unithiol/*pharmacology
MH  - Urea/metabolism
EDAT- 2006/07/15 09:00
MHDA- 2006/09/27 09:00
CRDT- 2006/07/15 09:00
PHST- 2005/09/19 00:00 [received]
PHST- 2005/10/12 00:00 [accepted]
PHST- 2006/07/15 09:00 [pubmed]
PHST- 2006/09/27 09:00 [medline]
PHST- 2006/07/15 09:00 [entrez]
AID - 10.1007/s10534-005-4020-3 [doi]
PST - ppublish
SO  - Biometals. 2006 Aug;19(4):389-98. doi: 10.1007/s10534-005-4020-3.