PMID- 16842499
OWN - NLM
STAT- MEDLINE
DCOM- 20060905
LR  - 20211025
IS  - 1474-9718 (Print)
IS  - 1474-9718 (Linking)
VI  - 5
IP  - 3
DP  - 2006 Jun
TI  - A critical role for the glial-derived neuromodulator D-serine in the age-related 
      deficits of cellular mechanisms of learning and memory.
PG  - 267-74
AB  - Age-associated deficits in learning and memory are closely correlated with 
      impairments of synaptic plasticity. Analysis of N-methyl-D-aspartate receptor 
      (NMDAr)-dependent long-term potentiation (LTP) in CA1 hippocampal slices 
      indicates that the glial-derived neuromodulator D-serine is required for the 
      induction of synaptic plasticity. During aging, the content of D-serine and the 
      expression of its synthesizing enzyme serine racemase are significantly decreased 
      in the hippocampus. Impaired LTP and NMDAr-mediated synaptic potentials in old 
      rats are rescued by exogenous D-serine. These results highlight the critical role 
      of glial cells and presumably astrocytes, through the availability of D-serine, 
      in the deficits of synaptic mechanisms of learning and memory that occur in the 
      course of aging.
FAU - Mothet, J P
AU  - Mothet JP
AD  - Neurobiologie de la Croissance et de la Senescence, UMR 549 INSERM, Faculte de 
      Medecine, Universite Paris-Descartes, 2 ter rue d'Alesia, 75014 Paris, France.
FAU - Rouaud, E
AU  - Rouaud E
FAU - Sinet, P-M
AU  - Sinet PM
FAU - Potier, B
AU  - Potier B
FAU - Jouvenceau, A
AU  - Jouvenceau A
FAU - Dutar, P
AU  - Dutar P
FAU - Videau, C
AU  - Videau C
FAU - Epelbaum, J
AU  - Epelbaum J
FAU - Billard, J-M
AU  - Billard JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Aging Cell
JT  - Aging cell
JID - 101130839
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 452VLY9402 (Serine)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Binding Sites
MH  - Hippocampus/cytology/drug effects
MH  - Learning/*physiology
MH  - Long-Term Potentiation/drug effects
MH  - Male
MH  - Memory/*physiology
MH  - Neuroglia/*metabolism
MH  - Neurotransmitter Agents/biosynthesis/*metabolism/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Serine/biosynthesis/*metabolism/pharmacology
MH  - Synaptic Transmission/drug effects/physiology
MH  - Time Factors
EDAT- 2006/07/18 09:00
MHDA- 2006/09/06 09:00
CRDT- 2006/07/18 09:00
PHST- 2006/07/18 09:00 [pubmed]
PHST- 2006/09/06 09:00 [medline]
PHST- 2006/07/18 09:00 [entrez]
AID - ACE216 [pii]
AID - 10.1111/j.1474-9726.2006.00216.x [doi]
PST - ppublish
SO  - Aging Cell. 2006 Jun;5(3):267-74. doi: 10.1111/j.1474-9726.2006.00216.x.