PMID- 1684256
OWN - NLM
STAT- MEDLINE
DCOM- 19920123
LR  - 20190912
IS  - 0174-7398 (Print)
IS  - 0174-7398 (Linking)
VI  - 419
IP  - 5
DP  - 1991
TI  - Parathyroid gastrin and parathormone-producing tumour in the Zollinger-Ellison 
      syndrome of MEN 1 origin.
PG  - 433-7
AB  - A case of Zollinger-Ellison syndrome of multiple endocrine neoplasia type 1 (MEN 
      1) origin with hyperparathyroidism and with a rise in serum gastrin due to an 
      unusual parathyroid "gastrinoma" has been investigated. The patient had multiple 
      endocrine tumours (pituitary and parathyroid), but no evidence of pancreatic or 
      duodenal gastrin-producing neoplasm. Radio-immunoassay, immunohistochemistry and 
      electron microscopy showed gastrin in one parathyroid adenoma. These findings, 
      together with a decrease of gastrinaemia after parathyroidectomy suggest that 
      true gastrin was produced by parathyroid tumour cells and that they themselves 
      may be the origin of the hypergastrinaemia. Our ultrastructural investigation 
      extends these observations and the results are discussed.
FAU - Santini, D
AU  - Santini D
AD  - Istituto di Anatomia Patologica, Policlinico S. Orsola, Universita di Bologna, 
      Italy.
FAU - Pasquinelli, G
AU  - Pasquinelli G
FAU - D'Alessandro, L
AU  - D'Alessandro L
FAU - Mazzoleni, G
AU  - Mazzoleni G
FAU - Taffurelli, M
AU  - Taffurelli M
FAU - Campione, O
AU  - Campione O
FAU - Marrano, D
AU  - Marrano D
FAU - Martinelli, G N
AU  - Martinelli GN
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Virchows Arch A Pathol Anat Histopathol
JT  - Virchows Archiv. A, Pathological anatomy and histopathology
JID - 8302198
RN  - 0 (Gastrins)
RN  - 0 (Parathyroid Hormone)
SB  - IM
MH  - Adenoma/metabolism
MH  - Female
MH  - Gastrins/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Microscopy, Electron
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/*complications
MH  - Parathyroid Glands/*metabolism
MH  - Parathyroid Hormone/*metabolism
MH  - Parathyroid Neoplasms/metabolism
MH  - Zollinger-Ellison Syndrome/etiology/*metabolism/pathology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1007/BF01605078 [doi]
PST - ppublish
SO  - Virchows Arch A Pathol Anat Histopathol. 1991;419(5):433-7. doi: 
      10.1007/BF01605078.