PMID- 16842597
OWN - NLM
STAT- MEDLINE
DCOM- 20070103
LR  - 20131121
IS  - 0906-6705 (Print)
IS  - 0906-6705 (Linking)
VI  - 15
IP  - 8
DP  - 2006 Aug
TI  - UVB-induced interleukin-18 production is downregulated by tannic acids in human 
      HaCaT keratinocytes.
PG  - 589-95
AB  - Tannic acids (TAs) are believed to be the key active components in plants, and 
      are believed to be responsible for their anti-inflammatory, anti-viral effects 
      and chemoprevention of cancer. However, the molecular mechanisms for the action 
      of TA are unclear. This study examined the effects of TA on cutaneous 
      inflammation with a human keratinocyte cell line (HaCaT). Interleukin-18 (IL-18) 
      has multiple effects upon various cells involved in inflammatory response. In 
      this study, the IL-18 mRNA expression and protein levels were reduced by a TA 
      pretreatment. UV radiation can trigger the induction of the p38 mitogen-activated 
      protein kinase (MAPK)-dependent signalling cascade. Immunoprecipitation and 
      Western blot analysis was performed to determine if TA regulate the MAPK 
      signalling pathway. TA significantly inhibited the activation of p38 MAPK and 
      extracellular signal-regulated protein kinases. Moreover, TA-inhibited UVB 
      enhanced the expression of the inflammatory mediators, IL-1, IL-6, tumor necrotic 
      factor-alpha, cyclooxygenase-2 and prostaglandin E(2) in UVB-irradiated HaCaT 
      cells. The topical application of TA on mouse skin treated with UVB irradiation 
      has shown that TA inhibited the formation of erythema. These findings suggest 
      that TA has significant anti-inflammatory effects on the UVB-induced response on 
      the skin and may be a candidate natural compound for the regulation of cutaneous 
      inflammation.
FAU - Park, Hyun Jeong
AU  - Park HJ
AD  - Department of Dermatology, St. Mary's Hospital, College of Medicine, The Catholic 
      University of Korea, Seoul, Korea. hjpark@catholic.ac.kr
FAU - Kim, Hee Jung
AU  - Kim HJ
FAU - Kwon, Hyun Jo
AU  - Kwon HJ
FAU - Lee, Jun Young
AU  - Lee JY
FAU - Cho, Baik Kee
AU  - Cho BK
FAU - Lee, Wang Jae
AU  - Lee WJ
FAU - Yang, Young
AU  - Yang Y
FAU - Cho, Dae Ho
AU  - Cho DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - 0 (Interleukin-18)
RN  - 0 (Tannins)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Dinoprostone/metabolism
MH  - *Down-Regulation
MH  - Erythema/metabolism
MH  - Humans
MH  - Inflammation
MH  - Interleukin-18/*biosynthesis/metabolism
MH  - Keratinocytes/metabolism
MH  - MAP Kinase Signaling System
MH  - Mice
MH  - Skin/metabolism/pathology
MH  - Tannins/*metabolism
MH  - Time Factors
MH  - *Ultraviolet Rays
EDAT- 2006/07/18 09:00
MHDA- 2007/01/04 09:00
CRDT- 2006/07/18 09:00
PHST- 2006/07/18 09:00 [pubmed]
PHST- 2007/01/04 09:00 [medline]
PHST- 2006/07/18 09:00 [entrez]
AID - EXD449 [pii]
AID - 10.1111/j.1600-0625.2006.00449.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2006 Aug;15(8):589-95. doi: 10.1111/j.1600-0625.2006.00449.x.