PMID- 16843097
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20150813
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 168
IP  - 2
DP  - 2006 Jul 15
TI  - Linking the human cytogenetic map with nucleotide sequence: the CCAP clone set.
PG  - 89-97
AB  - We present the completed dataset and clone repository of the Cancer Chromosome 
      Aberration Project (CCAP), an initiative developed and funded through the 
      intramural program of the U.S. National Cancer Institute, to provide seamless 
      linkage of human cytogenetic markers with the primary nucleotide sequence of the 
      human genome. Spaced at 1-2 Mb intervals across the human genome, 1,339 bacterial 
      artificial chromosome (BAC) clones have been localized to chromosomal bands 
      through high-resolution fluorescence in situ hybridization (FISH) mapping. Of 
      these clones, 99.8% can be positioned on the primary human genome sequence and 
      95% are placed at or close to their precise nucleotide starts and stops. This 
      dataset can be studied and manipulated within generally available public Web 
      sites. The clones are available from a commercial repository. The CCAP BAC clone 
      set provides anchors for the interrogation of gene and sequence involvement in 
      oncogenic and developmental disorders when the starting point is the recognition 
      of a structural, numerical, or interstitial chromosomal aberration. This dataset 
      also provides a current view of the quality and coherence of the available genome 
      sequence and insight into the nucleotide and three-dimensional structures that 
      manifest as Giemsa light and dark chromosomal banding patterns.
FAU - Jang, Wonhee
AU  - Jang W
AD  - National Center for Biotechnology Information, National Library of Medicine, 
      Bethesda, MD, USA.
FAU - Yonescu, Raluca
AU  - Yonescu R
FAU - Knutsen, Turid
AU  - Knutsen T
FAU - Brown, Theresa
AU  - Brown T
FAU - Reppert, Tricia
AU  - Reppert T
FAU - Sirotkin, Karl
AU  - Sirotkin K
FAU - Schuler, Gregory D
AU  - Schuler GD
FAU - Ried, Thomas
AU  - Ried T
FAU - Kirsch, Ilan R
AU  - Kirsch IR
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Base Composition/genetics
MH  - Base Sequence
MH  - *Chromosome Aberrations
MH  - *Chromosome Mapping
MH  - Chromosomes, Artificial, Bacterial/genetics
MH  - Chromosomes, Human, Pair 22/genetics
MH  - Clone Cells/metabolism
MH  - Cytogenetics
MH  - Genome, Human/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Neoplasms/*genetics
EDAT- 2006/07/18 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/07/18 09:00
PHST- 2005/12/29 00:00 [received]
PHST- 2006/01/03 00:00 [accepted]
PHST- 2006/07/18 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/07/18 09:00 [entrez]
AID - S0165-4608(06)00004-5 [pii]
AID - 10.1016/j.cancergencyto.2006.01.001 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2006 Jul 15;168(2):89-97. doi: 
      10.1016/j.cancergencyto.2006.01.001.