PMID- 16843102
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20221207
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 168
IP  - 2
DP  - 2006 Jul 15
TI  - Identification of 13q deletion, trisomy 1q, and IgH rearrangement as the most 
      frequent chromosomal changes found in Korean patients with multiple myeloma.
PG  - 124-32
AB  - The most frequent genetic aberrations in multiple myeloma (MM) are 13q deletions 
      and translocations involving the immunoglobulin heavy chain gene (IGH). There 
      have been no reports on the cytogenetic abnormalities found in Korean patients 
      with MM. We investigated the actual prevalence and prognostic value of 
      cytogenetic changes using fluorescence in situ hybridization (FISH). FISH studies 
      with 12 different specific probes for the regions containing the genes or 
      chromosome regions (13q, 1q, IGH, p53, MLL, p16, CEP 7, CEP 11, and CEP 12) were 
      performed in 128 patients. The most frequent change found was 13q deletion (48%), 
      followed by trisomy 1q (45%), IGH translocation (37%), and trisomy 11 (26%). 
      Among the three different probes used to detect 13q deletion, D13S25 (48/58) was 
      the most sensitive probe compared to RB (43/58) and D13S319 (39/58). Among the 
      patients showing one or more changes by FISH, 75% (82/110) had a 13q deletion, a 
      trisomy 1q, or an IGH translocation. Azotemia, anemia, thrombocytopenia, 
      intramedullary plasmacytosis, and stage were significantly associated with the 
      13q deletion; serum beta(2)-microglobulin, thrombocytopenia, and intramedullary 
      plasmacytosis were also related to trisomy 1q. The pattern of molecular 
      cytogenetic changes in Korean patients with MM is somewhat different from what 
      has been observed in reported Caucasian populations: 37 versus 50-70% with regard 
      to the IGH translocation. The prevalence of the 13q deletion was similar in 
      Korean and Caucasian populations, 48 versus 30-50%. We suggest that the detection 
      of at least these three genetic changes, 13q- trisomy 1q, and an IGH 
      rearrangement, would be helpful for follow-up of Korean patients with MM.
FAU - Bang, Soo-Mee
AU  - Bang SM
AD  - Department of Internal Medicine, Gachon Medical School, Gil Medical Center, 1198 
      Guwol-dong, Namdong-gu, Incheon 405-760, Korea.
FAU - Kim, Young Ree
AU  - Kim YR
FAU - Cho, Han Ik
AU  - Cho HI
FAU - Chi, Hyun Sook
AU  - Chi HS
FAU - Seo, Eul-Ju
AU  - Seo EJ
FAU - Park, Chan Jeoung
AU  - Park CJ
FAU - Yoo, Soo Jin
AU  - Yoo SJ
FAU - Kim, Hee Chan
AU  - Kim HC
FAU - Chun, Hong Gu
AU  - Chun HG
FAU - Min, Hyun Chung
AU  - Min HC
FAU - Oh, Bo Ra
AU  - Oh BR
FAU - Kim, Tae Young
AU  - Kim TY
FAU - Lee, Jae Hoon
AU  - Lee JH
FAU - Lee, Dong Soon
AU  - Lee DS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/*genetics
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Female
MH  - Gene Rearrangement, B-Lymphocyte, Heavy Chain/*genetics
MH  - Humans
MH  - Immunoglobulins/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Karyotyping
MH  - Korea
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/ethnology/*genetics
MH  - Ploidies
MH  - Regression Analysis
MH  - Sensitivity and Specificity
MH  - Survival Analysis
MH  - Trisomy/*genetics
MH  - Tumor Cells, Cultured
EDAT- 2006/07/18 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/07/18 09:00
PHST- 2005/10/19 00:00 [received]
PHST- 2006/02/06 00:00 [revised]
PHST- 2006/02/15 00:00 [accepted]
PHST- 2006/07/18 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/07/18 09:00 [entrez]
AID - S0165-4608(06)00121-X [pii]
AID - 10.1016/j.cancergencyto.2006.02.015 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2006 Jul 15;168(2):124-32. doi: 
      10.1016/j.cancergencyto.2006.02.015.