PMID- 16843863
OWN - NLM
STAT- MEDLINE
DCOM- 20061227
LR  - 20181201
IS  - 1091-255X (Print)
IS  - 1091-255X (Linking)
VI  - 10
IP  - 7
DP  - 2006 Jul-Aug
TI  - Quality of life in GERD patients: medical treatment versus antireflux surgery.
PG  - 934-9
AB  - Medical and surgical treatments are able to improve symptoms in patients with 
      gastroesophageal reflux disease (GERD). The aim of this study was to evaluate the 
      outcome in GERD patients without therapy, under continuous medical treatment, and 
      after laparoscopic antireflux surgery. Five hundred seventy-nine consecutive 
      patients underwent medical or surgical treatment for GERD-induced symptoms. 
      Patients were studied in detail before and after treatment by means of a symptom 
      questionnaire, endoscopy, esophageal manometry, 24-hour esophageal pH monitoring, 
      and a barium esophagogram. In addition, quality of life was measured by the means 
      of the Gastrointestinal Quality of Life Index (GIQLI) and the Health-Related 
      Quality of Life (HRQL) questionnaire. Surgery was indicated and performed in 351 
      patients with persistent or recurrent GERD symptoms and/or complications, and in 
      patients preferring surgery to medical treatment, despite the use of an adequate 
      medication. The remaining 228 patients were treated with proton pump inhibitors 
      (PPI) in the standard dose, or if required, the double dose. The outcome was 
      assessed 3 and 12 months after treatment. While symptoms and quality of life were 
      highly impaired in GERD patients without therapy compared with normal people, a 
      significant improvement was obtained by PPI therapy. Following surgery, quality 
      of life was normalized in all subsections and was significantly higher compared 
      with the medically treated group. These results stayed constant in short-term and 
      intermediate follow-up. Medical and surgical therapies are both able to improve 
      symptoms and quality of life in GERD patients. Nevertheless, the outcome is 
      significantly better following surgery. It can be suggested that surgical 
      treatment may be the more successful therapy in the long-term.
FAU - Ciovica, Ruxandra
AU  - Ciovica R
AD  - Department of Surgery, General Hospital Krems, Austria. ciovica@gmx.net
FAU - Gadenstatter, Michael
AU  - Gadenstatter M
FAU - Klingler, Anton
AU  - Klingler A
FAU - Lechner, Wolfgang
AU  - Lechner W
FAU - Riedl, Otto
AU  - Riedl O
FAU - Schwab, Gerhard P
AU  - Schwab GP
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Gastrointest Surg
JT  - Journal of gastrointestinal surgery : official journal of the Society for Surgery 
      of the Alimentary Tract
JID - 9706084
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Ulcer Agents)
RN  - D8TST4O562 (Pantoprazole)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/therapeutic use
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Biopsy
MH  - Endoscopy, Digestive System
MH  - Esophagus/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Gastroesophageal Reflux/*drug therapy/physiopathology/*surgery
MH  - Humans
MH  - Laparoscopy
MH  - Male
MH  - Manometry
MH  - Middle Aged
MH  - Omeprazole/therapeutic use
MH  - Pantoprazole
MH  - *Quality of Life
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2006/07/18 09:00
MHDA- 2006/12/28 09:00
CRDT- 2006/07/18 09:00
PHST- 2005/12/20 00:00 [received]
PHST- 2006/03/15 00:00 [revised]
PHST- 2006/04/05 00:00 [accepted]
PHST- 2006/07/18 09:00 [pubmed]
PHST- 2006/12/28 09:00 [medline]
PHST- 2006/07/18 09:00 [entrez]
AID - S1091-255X(06)00165-X [pii]
AID - 10.1016/j.gassur.2006.04.001 [doi]
PST - ppublish
SO  - J Gastrointest Surg. 2006 Jul-Aug;10(7):934-9. doi: 10.1016/j.gassur.2006.04.001.