PMID- 16844311
OWN - NLM
STAT- MEDLINE
DCOM- 20061220
LR  - 20220408
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 142
IP  - 1
DP  - 2006 Sep 29
TI  - Examination of behavioral deficits triggered by targeting Bdnf in fetal or 
      postnatal brains of mice.
PG  - 49-58
AB  - Human and animal studies have implicated brain-derived neurotrophic factor (BDNF) 
      in the etiology of psychiatric disorders. It is expressed in limbic regions of 
      the brain associated with the regulation of emotionality during fetal development 
      and in the adult animal. To further our understanding of the role of BDNF in the 
      modulation of mood and to distinguish its prenatal and postnatal functions, we 
      investigated and contrasted behavioral changes elicited by its depletion from 
      fetal or postnatal brains of mice. Two corresponding lines of BDNF conditional 
      knockout mice were subjected to a battery of behavioral tests assessing 
      locomotor, depressive, aggressive and anxiety-related behaviors. We found that 
      both lines of mutants were dramatically hyperactive during the light and dark 
      cycles and hyperaggressive. They also exhibited a depression-like phenotype in 
      the tail suspension test but not in the forced swim test. Interestingly, 
      depletion of BDNF from the fetal brain had more pronounced effects on aggressive 
      and depressive-like behaviors and led to deficits in 5-HT(2A) receptor content in 
      the medial frontal cortex, highlighting the importance of this neurotrophin 
      during development. We conclude that expression of BDNF both pre- and postnatally 
      is essential for normal modulation of behavior by neural circuits in the adult 
      animal.
FAU - Chan, J P
AU  - Chan JP
AD  - Department of Neuroscience, Tufts University School of Medicine, 136 Harrison 
      Avenue, Boston, MA 02111, USA.
FAU - Unger, T J
AU  - Unger TJ
FAU - Byrnes, J
AU  - Byrnes J
FAU - Rios, M
AU  - Rios M
LA  - eng
GR  - P30 NS047243/NS/NINDS NIH HHS/United States
GR  - R01 MH67817/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060714
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aggression/physiology
MH  - Animals
MH  - Animals, Newborn
MH  - Anxiety/genetics
MH  - Behavior, Animal
MH  - Blotting, Northern/methods
MH  - Blotting, Western/methods
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/deficiency/*physiology
MH  - Depression/genetics
MH  - Female
MH  - Gene Expression/genetics
MH  - Hindlimb Suspension/physiology
MH  - Immunohistochemistry/methods
MH  - Male
MH  - Maze Learning/physiology
MH  - Mental Disorders/*genetics/*physiopathology
MH  - Mice
MH  - Mice, Knockout
MH  - Motor Activity/genetics
MH  - Psychomotor Performance/physiology
MH  - Reaction Time/genetics
EDAT- 2006/07/18 09:00
MHDA- 2006/12/21 09:00
CRDT- 2006/07/18 09:00
PHST- 2006/02/18 00:00 [received]
PHST- 2006/05/09 00:00 [revised]
PHST- 2006/06/02 00:00 [accepted]
PHST- 2006/07/18 09:00 [pubmed]
PHST- 2006/12/21 09:00 [medline]
PHST- 2006/07/18 09:00 [entrez]
AID - S0306-4522(06)00754-8 [pii]
AID - 10.1016/j.neuroscience.2006.06.002 [doi]
PST - ppublish
SO  - Neuroscience. 2006 Sep 29;142(1):49-58. doi: 10.1016/j.neuroscience.2006.06.002. 
      Epub 2006 Jul 14.