PMID- 16844913
OWN - NLM
STAT- MEDLINE
DCOM- 20070116
LR  - 20200930
IS  - 0363-6135 (Print)
IS  - 0363-6135 (Linking)
VI  - 291
IP  - 6
DP  - 2006 Dec
TI  - Assessment of right ventricular diastolic suction in dogs with the use of wave 
      intensity analysis.
PG  - H3114-21
AB  - Diastolic suction (DS) can be defined as that property of the ventricle by means 
      of which it tends to refill itself during early diastole, independent of any 
      force from the atrium. Although thought to be significant in the left ventricle 
      (LV), DS in the right ventricle (RV) has received little attention, probably 
      because of RV geometry. Our recent LV studies have shown that DS is related to 
      both decreased elastance (i.e., tau, the relaxation time constant) and 
      end-systolic volume (V(LVES)), thus reconciling the two mechanisms that have been 
      used to explain the concept of DS. We hypothesized that RV DS would similarly 
      depend on tau and V(RVES). In six anesthetized open-chest dogs, aortic, RV, right 
      atrial (RA), pulmonary arterial (PA), and RV pericardial pressure, tricuspid 
      velocity, and PA flow were measured. V(RVES) was calculated by measuring 
      distances between eight ultrasonic crystals. An empirical index of relaxation, 
      tau', and V(RVES) were manipulated by volume loading/caval constriction and 
      isoproterenol/esmolol. We calculated the total energy (I(W-)) of the backward 
      expansion wave generated during RV relaxation and that component causing DS 
      [I(W-(DS))]; i.e., the energy remaining after tricuspid valve opening. I(W-) 
      [I(W-(DS)) also] was found to be inversely related to tau' and to V(RVES) i.e., 
      I(W-) = -8.85.e((-0.0423tau')).e([-0.0665(%V(RVES))]). Thus, as for the LV, the 
      energy of the backward-going wave generated by the RV during relaxation depends 
      on both the rate at which elastance decreases and the completeness of ejection. 
      Despite the thin wall and nonspherical shape of the RV, DS appears to be an 
      important mechanism.
FAU - Sun, Yichun
AU  - Sun Y
AD  - Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada 
      T2N 4N1.
FAU - Belenkie, Israel
AU  - Belenkie I
FAU - Wang, Jiun-Jr
AU  - Wang JJ
FAU - Tyberg, John V
AU  - Tyberg JV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060714
PL  - United States
TA  - Am J Physiol Heart Circ Physiol
JT  - American journal of physiology. Heart and circulatory physiology
JID - 100901228
RN  - 0 (Cardiotonic Agents)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Animals
MH  - Blood Circulation/physiology
MH  - Blood Flow Velocity
MH  - Blood Pressure/*physiology
MH  - Cardiotonic Agents/pharmacology
MH  - Dogs
MH  - Echocardiography, Doppler/*methods
MH  - Elasticity
MH  - Energy Metabolism
MH  - Isoproterenol/pharmacology
MH  - Models, Theoretical
MH  - Myocardial Contraction/drug effects/*physiology
MH  - Stroke Volume/physiology
MH  - Tricuspid Valve/physiology
MH  - Ventricular Function, Right/*physiology
EDAT- 2006/07/18 09:00
MHDA- 2007/01/17 09:00
CRDT- 2006/07/18 09:00
PHST- 2006/07/18 09:00 [pubmed]
PHST- 2007/01/17 09:00 [medline]
PHST- 2006/07/18 09:00 [entrez]
AID - 00853.2005 [pii]
AID - 10.1152/ajpheart.00853.2005 [doi]
PST - ppublish
SO  - Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3114-21. doi: 
      10.1152/ajpheart.00853.2005. Epub 2006 Jul 14.