PMID- 16845218
OWN - NLM
STAT- MEDLINE
DCOM- 20061228
LR  - 20200106
IS  - 1734-1140 (Print)
IS  - 1734-1140 (Linking)
VI  - 58
IP  - 3
DP  - 2006 May-Jun
TI  - Effect of MPEP treatment on brain-derived neurotrophic factor gene expression.
PG  - 427-30
AB  - Treatment with most antidepressants induces expression of the gene coding for 
      brain-derived neurotrophic factor (BDNF) in the hippocampus (and cerebral 
      cortex). Recent data indicate antidepressant-like activity of group I mGlu 
      receptor (mGluR1 and mGluR5) antagonists in animal tests/models. We now report 
      that chronic treatment with 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a 
      selective mGlu5 receptor antagonist, increased hippocampal but reduced cortical 
      BDNF mRNA level (Northern blot). Desipramine, a classic antidepressant, increased 
      BDNF mRNA level in both examined brain regions. This is the first demonstration 
      that an antagonist of mGlu5 receptors, like a majority of well-established 
      antidepressants, induces hippocampal BDNF gene expression. A significance of MPEP 
      ability to reduce cortical BDNF needs further study. Nevertheless, this 
      observation further indicates a potential antidepressant activity of the group I 
      mGlu receptor antagonists in human depression.
FAU - Legutko, Beata
AU  - Legutko B
AD  - Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 
      Krakow, Poland. nflegutk@cyf-kr.edu.pl
FAU - Szewczyk, Bernadeta
AU  - Szewczyk B
FAU - Pomierny-Chamiolo, Lucyna
AU  - Pomierny-Chamiolo L
FAU - Nowak, Gabriel
AU  - Nowak G
FAU - Pilc, Andrzej
AU  - Pilc A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Pharmacol Rep
JT  - Pharmacological reports : PR
JID - 101234999
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GRM5 protein, human)
RN  - 0 (Grm5 protein, rat)
RN  - 0 (Pyridines)
RN  - 0 (Receptor, Metabotropic Glutamate 5)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 7VC0YVI27Y (6-methyl-2-(phenylethynyl)pyridine)
RN  - TG537D343B (Desipramine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Cerebral Cortex/drug effects
MH  - Desipramine/pharmacology
MH  - Gene Expression/drug effects
MH  - Hippocampus/drug effects
MH  - Male
MH  - Pyridines/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Metabotropic Glutamate 5
MH  - Receptors, Metabotropic Glutamate/antagonists & inhibitors
EDAT- 2006/07/18 09:00
MHDA- 2006/12/29 09:00
CRDT- 2006/07/18 09:00
PHST- 2005/11/25 00:00 [received]
PHST- 2006/04/19 00:00 [revised]
PHST- 2006/07/18 09:00 [pubmed]
PHST- 2006/12/29 09:00 [medline]
PHST- 2006/07/18 09:00 [entrez]
PST - ppublish
SO  - Pharmacol Rep. 2006 May-Jun;58(3):427-30.