PMID- 16845517
OWN - NLM
STAT- MEDLINE
DCOM- 20071025
LR  - 20211110
IS  - 0937-4477 (Print)
IS  - 0937-4477 (Linking)
VI  - 263
IP  - 12
DP  - 2006 Dec
TI  - Laryngopharyngeal reflux disease with nocturnal gastric acid breakthrough while 
      on proton pump inhibitor therapy.
PG  - 1121-6
AB  - Laryngopharyngeal reflux disease (LPRD) with nocturnal recovery of gastric acid 
      secretion (nocturnal acid breakthrough: NAB) with proton pump inhibitors (PPI) 
      was first reported. A 79-year-old Japanese woman complained of globus pharyngeus 
      and mild heartburn was examined with the use of tetra-probe 24-h pH monitoring. 
      She had been treated for reflux esophagitis (GERD) for 12 months prior to her 
      visit to our office. She took Lansoprazole (30 mg/day) before dinner every day. 
      The tetra-probe 24-h pH monitoring revealed that the recovery of gastric acid 
      secretion occurred 6.5 h after taking the dose of PPI. The intragastric pH 
      dropped < 4 at about 23:00 and remained below that level for 4 h and 50 min. The 
      24-h pH-metry at each probe showed that the nocturnal recovery of gastric acid 
      secretion with PPI (NAB on PPI) influenced gastroesophageal and laryngopharyngeal 
      refluxes. The symptoms of the pharynx and esophagus disappeared after taking H2 
      receptor antagonist (H2RA) additionally before bedtime.
FAU - Sato, Kiminori
AU  - Sato K
AD  - Department of Otolaryngology, Head and Neck Surgery, Kurume University, School of 
      Medicine, 67 Asahi-machi, Kurume 830-0011, Japan. kimisato@oct-net.ne.jp
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20060715
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Ede1 protein, S cerevisiae)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Saccharomyces cerevisiae Proteins)
SB  - IM
MH  - Aged
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Arytenoid Cartilage
MH  - Female
MH  - Gastric Acid/*metabolism
MH  - Gastric Acidity Determination/instrumentation
MH  - Gastroesophageal Reflux/*drug therapy/*epidemiology/*metabolism
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Laryngeal Edema/pathology
MH  - Laryngoscopy
MH  - *Proton Pump Inhibitors
MH  - Saccharomyces cerevisiae Proteins
MH  - Time Factors
EDAT- 2006/07/18 09:00
MHDA- 2007/10/27 09:00
CRDT- 2006/07/18 09:00
PHST- 2005/09/08 00:00 [received]
PHST- 2006/05/17 00:00 [accepted]
PHST- 2006/07/18 09:00 [pubmed]
PHST- 2007/10/27 09:00 [medline]
PHST- 2006/07/18 09:00 [entrez]
AID - 10.1007/s00405-006-0117-8 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2006 Dec;263(12):1121-6. doi: 
      10.1007/s00405-006-0117-8. Epub 2006 Jul 15.