PMID- 16845646
OWN - NLM
STAT- MEDLINE
DCOM- 20070314
LR  - 20181201
IS  - 1091-4269 (Print)
IS  - 1091-4269 (Linking)
VI  - 23
IP  - 8
DP  - 2006
TI  - Lamotrigine adjunctive treatment in resistant unipolar depression: an open, 
      descriptive study.
PG  - 485-8
AB  - Adjunctive treatment of lamotrigine compared to other antidepressants in the 
      treatment of partially responsive, poorly functioning patients with unipolar 
      depression was assessed. Fourteen consenting patients with confirmed DSM-IV-R 
      diagnosis of unipolar depression were identified as treatment resistant. All 
      patients failed at least two 8-week treatment trials with antidepressants. All 
      were treated with lamotrigine as an adjunct to other antidepressants for at least 
      6 months. The primary effectiveness measure was the Clinical Global Impression 
      Severity subscale (CGI-S). Other scales included the Montgomery-Asberg Depression 
      Scale (MADRS) and the Global Assessment of Functioning Scale (GAF). Monitoring 
      for skin rashes, headache, dizziness, somnolence, and gastrointestinal 
      disturbances was carried out to assess for adverse events. Baseline measures 
      prior to adding lamotrigine were compared to those at 8 weeks and 6 months with 
      adjunctive treatment. Twelve patients of the total (n=14) completed the trial, 
      and two discontinued treatment. There was significant, rapid, and robust 
      resolution in symptoms in all effectiveness measures, including the core symptoms 
      of depression, as shown by the changes from baseline in CGI-S, and MADRS at 8 
      weeks. Social and occupational functioning was significantly improved at 6 
      months. Eight patients returned to gainful employment or started schooling. 
      Patients tolerated the adjunctive lamotrigine treatment well. Lamotrigine may 
      have antidepressant properties in patients with unipolar depression and may have 
      an earlier onset of action when given in combination with antidepressants.
CI  - Published 2006 Wiley-Liss, Inc.
FAU - Gabriel, Adel
AU  - Gabriel A
AD  - Faculty of Medicine, University of Calgary, 2000 Pegasus Road, Calgary, Alberta, 
      Canada. gabriel@ucalgary.ca
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Depress Anxiety
JT  - Depression and anxiety
JID - 9708816
RN  - 0 (Anticonvulsants)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Triazines)
RN  - U3H27498KS (Lamotrigine)
SB  - IM
MH  - Adult
MH  - Anticonvulsants/*administration & dosage/adverse effects
MH  - Antidepressive Agents/*administration & dosage/adverse effects
MH  - Depressive Disorder, Major/diagnosis/*drug therapy/psychology
MH  - Drug Resistance
MH  - Drug Therapy, Combination
MH  - Electroconvulsive Therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lamotrigine
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Quality of Life/psychology
MH  - Treatment Outcome
MH  - Triazines/*administration & dosage/adverse effects
EDAT- 2006/07/18 09:00
MHDA- 2007/03/16 09:00
CRDT- 2006/07/18 09:00
PHST- 2006/07/18 09:00 [pubmed]
PHST- 2007/03/16 09:00 [medline]
PHST- 2006/07/18 09:00 [entrez]
AID - 10.1002/da.20211 [doi]
PST - ppublish
SO  - Depress Anxiety. 2006;23(8):485-8. doi: 10.1002/da.20211.