PMID- 16846452
OWN - NLM
STAT- MEDLINE
DCOM- 20060919
LR  - 20220321
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 17
IP  - 5
DP  - 2006 Aug
TI  - Atopy patch testing in children with asthma and rhinitis symptoms allergic to 
      house dust mite.
PG  - 346-50
AB  - The atopy patch test (APT) is generally used to assess immunoglobulin E (IgE) 
      mediated sensitization to allergens in patients with atopic dermatitis, but its 
      diagnostic role in children with respiratory allergy is still controversial. The 
      aim of the study was to evaluate APT with house dust mite (HDM) in children with 
      asthma and rhinitis symptoms allergic to HDM and its relevance to skin prick test 
      (SPT) diameters and specific IgE levels. The study population consisted of 33 
      children, aged 8-16 yr (median: 12 yr) with asthma and 30 children with allergic 
      rhinitis in the same age range (median: 11 yr). All patients had positive SPT 
      results and high serum specific IgE levels for Dermatophagoides pteronyssinus APT 
      was performed on back skin of all patients with 200 index of reactivity (IR)/ml 
      of D. pteronyssinus allergen extracts in petrolatum (Stallerpatch) and evaluated 
      at 72 h. Of 63 patients, 16 (25%) showed a positive patch test result. APT with 
      HDM showed 30% (10/33) positivity among the patients with asthma and 20% (6/30) 
      positivity among the patients with allergic rhinitis. APT presented no 
      significant correlation with age, SPT diameter, serum total and specific IgE 
      levels for D. pteronyssinus, nasal provocation test or pulmonary function test 
      results. Patch testing with HDM may partly identify mite sensitive children with 
      respiratory allergy. Positive APT results may imply that delayed hypersensitivity 
      reactions play a role in children with asthma and rhinitis allergic to HDM.
FAU - Guler, N
AU  - Guler N
AD  - Department of Pediatrics, Division of Allergy and Chest Diseases, Istanbul 
      Medical Faculty, Istanbul University, Istanbul, Turkey. nerminguler@yahoo.com
FAU - Kirerleri, E
AU  - Kirerleri E
FAU - Tamay, Z
AU  - Tamay Z
FAU - Ones, U
AU  - Ones U
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Antigens, Dermatophagoides)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Antigens, Dermatophagoides/adverse effects/*immunology
MH  - Child
MH  - Dermatophagoides pteronyssinus/*immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*immunology
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Patch Tests/*methods
MH  - Rhinitis, Allergic, Perennial/*immunology
EDAT- 2006/07/19 09:00
MHDA- 2006/09/20 09:00
CRDT- 2006/07/19 09:00
PHST- 2006/07/19 09:00 [pubmed]
PHST- 2006/09/20 09:00 [medline]
PHST- 2006/07/19 09:00 [entrez]
AID - PAI422 [pii]
AID - 10.1111/j.1399-3038.2006.00422.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2006 Aug;17(5):346-50. doi: 
      10.1111/j.1399-3038.2006.00422.x.