PMID- 1684770
OWN - NLM
STAT- MEDLINE
DCOM- 19920213
LR  - 20191210
IS  - 0306-3623 (Print)
IS  - 0306-3623 (Linking)
VI  - 22
IP  - 5
DP  - 1991
TI  - Effect of serotonin depletion by p-chlorophenylalanine upon discriminative 
      behaviours.
PG  - 889-93
AB  - 1. Para-chlorophenylalanine (p-CPA), a competitive inhibitor of the serotonin 
      (5-HT) synthesis enzyme tryptophan hydroxylase, was administered to rats at a 
      dosage (100 mg/kg daily for 3 days) that depletes 5-HT. 2. Different groups of 
      these rats were previously trained to discriminate the interoceptive stimuli 
      produced by amphetamine, cathinone, 3,4-methylenedioxymethamphetamine (MDMA), 
      N-ethyl-3,4-methylenedioxyamphetamine (MDE), fenfluramine or yohimbine, and the 
      effect of p-CPA pretreatment upon their discriminative performance was compared 
      with the effect of saline (control) pretreatment. 3. p-CPA was shown to have no 
      effect upon the dopaminergically-mediated stimuli produced by the stimulants 
      amphetamine and cathinone or upon yohimbine performance. 4. p-CPA significantly 
      decreased discriminative performance with the serotonergic releasing drugs MDMA, 
      MDE and fenfluramine. This decrease in discriminative performance returned to 
      pre-p-CPA (criterion) levels at a time (9-12 days) when 5-HT has been reported to 
      replete to normal brain concentrations. 5. It is concluded that p-CPA 
      pretreatment lowers brain 5-HT and, in turn, significantly decreases the ability 
      of rats to discriminate centrally active drugs whose interoceptive cueing stimuli 
      are mediated by 5-HT neurons.
FAU - Schechter, M D
AU  - Schechter MD
AD  - Department of Pharmacology, Northeastern Ohio Universities College of Medicine, 
      Rootstown 44272.
LA  - eng
GR  - NIDA 04181/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Gen Pharmacol
JT  - General pharmacology
JID - 7602417
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Serotonin Antagonists)
RN  - 333DO1RDJY (Serotonin)
RN  - R5J7E3L9SP (Fenclonine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain Chemistry/drug effects
MH  - Central Nervous System Stimulants/pharmacology
MH  - Discrimination, Psychological/*drug effects
MH  - Dopamine/physiology
MH  - Fenclonine/*pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/*physiology
MH  - Serotonin Antagonists/*pharmacology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 0306-3623(91)90226-V [pii]
AID - 10.1016/0306-3623(91)90226-v [doi]
PST - ppublish
SO  - Gen Pharmacol. 1991;22(5):889-93. doi: 10.1016/0306-3623(91)90226-v.