PMID- 16847813
OWN - NLM
STAT- MEDLINE
DCOM- 20060825
LR  - 20221007
IS  - 0393-6155 (Print)
IS  - 0393-6155 (Linking)
VI  - 21
IP  - 2
DP  - 2006 Apr-Jun
TI  - Human kallikrein 13 expression in salivary gland tumors.
PG  - 106-10
AB  - The human kallikrein 13 protein (hK13) is expressed in many normal tissues. 
      Petraki et al have previously described presence of hK13 in salivary gland 
      tissue, localized to duct epithelia and some acinar cells. The aim of this study 
      was to determine whether hK13 is expressed in salivary gland tissues and salivary 
      gland tumors (both benign and malignant), in order to compare normal with tumor 
      tissues. Pleomorphic adenomas (PA), adenoid cystic carcinomas (ACC), polymorphous 
      low grade adenocarcinomas (PLGA), acinic cell carcinomas (ACI), mucoepidermoid 
      carcinomas (MEC) and adenocarcinomas not otherwise specified (ANOS) of both minor 
      and major salivary glands were examined. The results of this study indicate that 
      most salivary gland tumors show high levels of expression of hK13. Overall, 
      staining in PA was significantly less than that seen in normal salivary gland 
      tissue. PLGA, ACC and ANOS each stained significantly more than normal salivary 
      gland tissue while MEC and ACI did not. Ductal cells and cells lining duct-like 
      structures showed a higher intensity of staining than non-ductal cells in most 
      tumors. Tumors which exhibited only non-ductal cells also exhibited cytoplasmic 
      staining. In conclusion, we demonstrate the high expression of hK13 in several 
      common salivary gland tumors.
FAU - Darling, M R
AU  - Darling MR
AD  - Division of Oral Pathology, Department of Pathology, University of Western 
      Ontario, London, Canada. mark.darling@schulich.uwo.ca
FAU - Jackson-Boeters, L
AU  - Jackson-Boeters L
FAU - Daley, T D
AU  - Daley TD
FAU - Diamandis, E P
AU  - Diamandis EP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Biol Markers
JT  - The International journal of biological markers
JID - 8712411
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.4.21.- (KLK13 protein, human)
RN  - EC 3.4.21.- (Kallikreins)
SB  - IM
MH  - Adenocarcinoma/metabolism
MH  - Adenoma, Pleomorphic/metabolism
MH  - *Biomarkers, Tumor
MH  - Carcinoma, Adenoid Cystic/*metabolism
MH  - Carcinoma, Mucoepidermoid/metabolism
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Kallikreins/*biosynthesis
MH  - Mouth Mucosa/*metabolism
MH  - Prognosis
MH  - Salivary Gland Neoplasms/*genetics
MH  - Salivary Glands/metabolism
EDAT- 2006/07/19 09:00
MHDA- 2006/08/26 09:00
CRDT- 2006/07/19 09:00
PHST- 2006/07/19 09:00 [pubmed]
PHST- 2006/08/26 09:00 [medline]
PHST- 2006/07/19 09:00 [entrez]
AID - 10.1177/172460080602100206 [doi]
PST - ppublish
SO  - Int J Biol Markers. 2006 Apr-Jun;21(2):106-10. doi: 10.1177/172460080602100206.