PMID- 16854410
OWN - NLM
STAT- MEDLINE
DCOM- 20061201
LR  - 20060821
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 545
IP  - 1
DP  - 2006 Sep 1
TI  - Distinct roles of diverse nuclear factor-kappaB complexes in neuropathological 
      mechanisms.
PG  - 22-8
AB  - The nuclear transcription factors kappaB (NF-kappaB) function as key regulators 
      of physiological processes in the central nervous system. Aberrant regulation of 
      NF-kappaB can underlie neurological disorders associated with neurodegeneration. 
      A large number of studies have reported a dual role of NF-kappaB in regulating 
      neuron survival in pathological conditions. A recent progress in understanding 
      the mechanisms responsible for opposite effects elicited by NF-kappaB in brain 
      dysfunctions arises from the identification of diverse NF-kappaB complexes 
      specifically involved in the mechanism of neuronal cell death or cell survival. 
      We here discuss the latest findings and consider the therapeutic potential of 
      targeting distinct NF-kappaB complexes for the treatment of neurodegenerative 
      disorders and memory dysfunctions.
FAU - Pizzi, Marina
AU  - Pizzi M
AD  - Division of Pharmacology and Experimental Therapeutics, Department of Biomedical 
      Sciences and Biotechnologies, School of Medicine, University of Brescia, I 25123, 
      Italy. pizzi@med.unibs.it
FAU - Spano, Pierfranco
AU  - Spano P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060616
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (NF-kappa B)
SB  - IM
MH  - Animals
MH  - Cell Death
MH  - Cell Survival
MH  - Dimerization
MH  - Humans
MH  - NF-kappa B/*physiology
MH  - Neurodegenerative Diseases/*metabolism/pathology
MH  - Neurons/pathology
RF  - 95
EDAT- 2006/07/21 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/07/21 09:00
PHST- 2005/12/23 00:00 [received]
PHST- 2006/03/22 00:00 [revised]
PHST- 2006/06/13 00:00 [accepted]
PHST- 2006/07/21 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/07/21 09:00 [entrez]
AID - S0014-2999(06)00645-5 [pii]
AID - 10.1016/j.ejphar.2006.06.027 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2006 Sep 1;545(1):22-8. doi: 10.1016/j.ejphar.2006.06.027. Epub 
      2006 Jun 16.