PMID- 16854566
OWN - NLM
STAT- MEDLINE
DCOM- 20070126
LR  - 20221207
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 87
IP  - 1-3
DP  - 2006 Oct
TI  - No evidence for an association between the BDNF Val66Met polymorphism and 
      schizophrenia or personality traits.
PG  - 45-7
AB  - Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor 
      family, which plays a critical role in neurodevelopment. Based on the 
      neurodevelopmental hypothesis, the BDNF gene has been a candidate locus for 
      schizophrenia. In Caucasians, recent studies identified an association with the 
      Val66Met polymorphism, which has been suggested to affect episodic memory and 
      hippocampal function in humans. However, in other populations, the association 
      has not been replicated. In the present study, we investigated the association 
      between the Val66Met polymorphism of the gene and schizophrenia in 401 Japanese 
      patients with schizophrenia and 569 controls. As a result, we did not observe a 
      significant difference in genotypic distribution or allele frequencies between 
      the patients and controls (chi2=0.56, df=2, p=0.76 and chi2=0.39, df=1, p=0.53, 
      respectively). We also investigated the association between the polymorphism and 
      personality traits in the controls; however, no significant association was 
      observed. Thus, the present study did not provide evidence for an association 
      between the BDNF gene and schizophrenia or personality traits in the Japanese 
      population.
FAU - Tochigi, Mamoru
AU  - Tochigi M
AD  - Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 
      7-3-1 Hongo, Bunkyo, Tokyo113-8655, Japan.
FAU - Otowa, Takeshi
AU  - Otowa T
FAU - Suga, Motomu
AU  - Suga M
FAU - Rogers, Mark
AU  - Rogers M
FAU - Minato, Takanobu
AU  - Minato T
FAU - Yamasue, Hidenori
AU  - Yamasue H
FAU - Kasai, Kiyoto
AU  - Kasai K
FAU - Kato, Nobumasa
AU  - Kato N
FAU - Sasaki, Tsukasa
AU  - Sasaki T
LA  - eng
PT  - Journal Article
DEP - 20060718
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Asian People/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Gene Expression/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Personality Disorders/diagnosis/etiology/*genetics
MH  - Personality Inventory
MH  - Polymorphism, Genetic/*genetics
MH  - Schizophrenia/*genetics
MH  - *Schizophrenic Psychology
EDAT- 2006/07/21 09:00
MHDA- 2007/01/27 09:00
CRDT- 2006/07/21 09:00
PHST- 2006/04/03 00:00 [received]
PHST- 2006/06/13 00:00 [revised]
PHST- 2006/06/18 00:00 [accepted]
PHST- 2006/07/21 09:00 [pubmed]
PHST- 2007/01/27 09:00 [medline]
PHST- 2006/07/21 09:00 [entrez]
AID - S0920-9964(06)00295-7 [pii]
AID - 10.1016/j.schres.2006.06.029 [doi]
PST - ppublish
SO  - Schizophr Res. 2006 Oct;87(1-3):45-7. doi: 10.1016/j.schres.2006.06.029. Epub 
      2006 Jul 18.