PMID- 16854621
OWN - NLM
STAT- MEDLINE
DCOM- 20061128
LR  - 20191210
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 117
IP  - 9
DP  - 2006 Sep
TI  - Abnormalities in central auditory maturation in children with language-based 
      learning problems.
PG  - 1949-56
AB  - OBJECTIVE: To examine maturation of the central auditory pathways in children 
      with language-based learning problems (LP). METHODS: Cortical auditory evoked 
      potentials (CAEPs) recorded from 26 children with LP were compared to CAEPs 
      recorded from 38 typical children. CAEP responses were recorded in response to a 
      speech sound, /uh/, which was presented in a stimulus train with decreasing 
      inter-stimulus intervals (ISIs) of 2000, 1000, 560, and 360 ms. RESULTS: We 
      identified three atypical morphological categories of CAEP responses in the LP 
      group. Category 1 responses revealed delayed P1 latencies and absent N1/P2 
      components. Category 2 responses revealed typical P1 responses, but delayed N1 
      and P2 responses. Category 3 responses revealed generally low-amplitude CAEP 
      responses. A fourth sub-group of LP children had normal CAEP responses. 
      CONCLUSIONS: Overall, the majority of children with LP had abnormal CAEP 
      responses. These children fell into distinct categories based on the 
      abnormalities in maturational patterns of their CAEP responses. SIGNIFICANCE: We 
      describe a rate sensitive stimulation paradigm which may be used to identify and 
      categorize LP children who exhibit abnormal patterns of central auditory 
      maturation.
FAU - Gilley, Phillip M
AU  - Gilley PM
AD  - The University of Texas at Dallas, School of Behavioral and Brain Sciences, 
      Callier Advanced Hearing Research Center, 1966 Inwood Rd., Dallas, TX 75206, USA. 
      pgilley@utdallas.edu
FAU - Sharma, Anu
AU  - Sharma A
FAU - Dorman, Michael
AU  - Dorman M
FAU - Martin, Kathryn
AU  - Martin K
LA  - eng
GR  - DC006257/DC/NIDCD NIH HHS/United States
GR  - R01DC004552/DC/NIDCD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060718
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Acoustic Stimulation/methods
MH  - Adolescent
MH  - Age Factors
MH  - Auditory Cortex/*physiology
MH  - Child
MH  - Child Development/*physiology
MH  - Electroencephalography/methods
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Humans
MH  - Language Disorders/*physiopathology
MH  - Learning Disabilities/*physiopathology
MH  - Male
MH  - Time Factors
EDAT- 2006/07/21 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/07/21 09:00
PHST- 2005/10/05 00:00 [received]
PHST- 2006/03/07 00:00 [revised]
PHST- 2006/05/14 00:00 [accepted]
PHST- 2006/07/21 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/07/21 09:00 [entrez]
AID - S1388-2457(06)00227-6 [pii]
AID - 10.1016/j.clinph.2006.05.015 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2006 Sep;117(9):1949-56. doi: 10.1016/j.clinph.2006.05.015. 
      Epub 2006 Jul 18.