PMID- 16857002
OWN - NLM
STAT- MEDLINE
DCOM- 20061207
LR  - 20060721
IS  - 1397-3142 (Print)
IS  - 1397-3142 (Linking)
VI  - 10
IP  - 5
DP  - 2006 Aug
TI  - Successful unrelated mismatched cord blood transplantation in a child with 
      malignant infantile osteopetrosis.
PG  - 629-31
AB  - Allogeneic hematopoietic stem cell transplantation represents the only curative 
      option for malignant infantile osteopetrosis (MIOP), a rare disease of infants 
      and young children, characterized by excessive accumulation of mineralized bone 
      and abnormal hematopoiesis. We report a case of successful engraftment and stable 
      full-donor chimerism in a patient with MIOP who underwent unrelated donor cord 
      blood transplantation (CBT). The donor was 2-loci human leukocyte antigen 
      (HLA)-mismatch. After a conditioning regimen based on the combination of 
      busulfan, cyclophosphamide, total body irradiation, and antithymocyte globulin, 
      the patient received a dose of 3.85 x 10(7)/kg of nucleated cells. Neutrophil and 
      platelet engraftment had been achieved by day +33 and +82, respectively, and the 
      patient was discharged home on day +89. A successful engraftment of donor 
      hematopoiesis was demonstrated and the child experienced grade II acute 
      graft-vs.-host disease (GVHD) involving the skin only. A remarkable but 
      non-progressive decrease in lumbar spine bone mineral density was observed in the 
      first nine months post-transplant. This case suggests that unrelated donor CBT 
      may be a feasible option in case of unavailability of a fully HLA-matched related 
      or unrelated donor.
FAU - Jaing, Tang-Her
AU  - Jaing TH
AD  - Division of Hematology/Oncology, Department of Pediatrics, Chang Gung University 
      and Children's Hospital, Taoyuan, Taiwan. jaing001@cgmh.org.tw
FAU - Hou, Jia-Woei
AU  - Hou JW
FAU - Chen, Shih-Hsiang
AU  - Chen SH
FAU - Huang, I-Anne
AU  - Huang IA
FAU - Wang, Chao-Jan
AU  - Wang CJ
FAU - Lee, Wei-I
AU  - Lee WI
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
SB  - IM
MH  - *Cord Blood Stem Cell Transplantation
MH  - Humans
MH  - Infant
MH  - Male
MH  - Osteopetrosis/*therapy
MH  - Transplantation, Homologous
EDAT- 2006/07/22 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/07/22 09:00
PHST- 2006/07/22 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/07/22 09:00 [entrez]
AID - PTR537 [pii]
AID - 10.1111/j.1399-3046.2006.00537.x [doi]
PST - ppublish
SO  - Pediatr Transplant. 2006 Aug;10(5):629-31. doi: 10.1111/j.1399-3046.2006.00537.x.