PMID- 16857128
OWN - NLM
STAT- MEDLINE
DCOM- 20070410
LR  - 20111117
IS  - 0412-4081 (Print)
IS  - 0412-4081 (Linking)
VI  - 42
IP  - 6
DP  - 2006 Jun
TI  - [Clinical characteristic of optic neuritis and its relevancy with human leukocyte 
      antigen].
PG  - 501-6
AB  - OBJECTIVE: To investigate clinical characteristics of optic neuritis and its 
      association with HLA (human leukocyte antigen). METHOD: The clinical data of 42 
      patients with optic neuritis were collected and flow polymerase chain 
      reaction-reverse sequence specific oligonucleotide probe (PCR-rSSOP) was used to 
      determine the genotype of HLA-DRB1. RESULTS: Two patients confirmed as Leber 
      hereditary optic neuropathy by gene sequencing were excluded from the study. The 
      complaint of pain was found in the patients (31/40) of optic neuritis. The visual 
      field defect varied with patients and central and pericentral scotoma were 
      demonstrated in 7 patients of 17. Of 40 patients with optic neuritis, 20 (50.0%) 
      showed multifocal brain lesions in white matter by MR scanning. 26 of 38 patients 
      had increased STIR signals. Inflammatory demyelinating changes were found in 
      cerebral spinal fluid in 21 patients (80.8%). Out of demonstrated brain abnormal 
      was revealed in 29 (72.5%) patients using MRI and/or CSF examination. The rate of 
      HLA-DRB1(*)15 in the patients (35.0%) was much higher than control (19.4%), 
      (chi(2) = 4.2328, P = 0.0397). Frequencies of HLA-DRB1(*)15 increased 
      significantly in 26 female patients. The increased frequencies of HLA-DRB1(*)15 
      were associated with CSF abnormality and no relevancy was found with onset times, 
      brain MR changes and increase of optic nerve signals. Acute optic neuritis 
      responded well to intravenous megadose of methylprednisolone or immunoglobulin. 
      CONCLUSIONS: Most of optic neuritis was characterized as clinical inflammatory 
      demyelinating disease. HLA-DRB1(*)15 might correlated with genetic susceptibility 
      of female patients with optic neuritis.
FAU - Lai, Chun-tao
AU  - Lai CT
AD  - Department of Neurology, Tongren Hospital, Capital University of Medical Science, 
      Beijing 100730, China. laichunt@163.com
FAU - Li, Wei
AU  - Li W
FAU - Sun, Yan-bin
AU  - Sun YB
FAU - Meng, Chao
AU  - Meng C
FAU - Chi, Ke-mei
AU  - Chi KM
FAU - Lu, Chang-feng
AU  - Lu CF
FAU - Yu, Hua-feng
AU  - Yu HF
FAU - Zhang, Zhi-xin
AU  - Zhang ZX
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yan Ke Za Zhi
JT  - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
JID - 16210540R
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Child
MH  - Demyelinating Diseases/diagnosis
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optic Neuritis/diagnosis/drug therapy/*genetics
MH  - Sex Factors
EDAT- 2006/07/22 09:00
MHDA- 2007/04/11 09:00
CRDT- 2006/07/22 09:00
PHST- 2006/07/22 09:00 [pubmed]
PHST- 2007/04/11 09:00 [medline]
PHST- 2006/07/22 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yan Ke Za Zhi. 2006 Jun;42(6):501-6.