PMID- 16857270
OWN - NLM
STAT- MEDLINE
DCOM- 20061129
LR  - 20151119
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 179
IP  - 1-2
DP  - 2006 Oct
TI  - MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic 
      amyotrophic lateral sclerosis (sALS).
PG  - 87-93
AB  - Recent studies suggest that monocyte activation may play a role in ALS 
      pathogenesis. Therefore, monocyte CCR2, the receptor for monocyte chemoattractant 
      protein-1 (MCP-1), and plasma levels of MCP-1 were measured in 42 sALS patients, 
      38 healthy and 34 age-related macular degeneration (ARMD) controls. MCP-1 was 
      elevated in both sALS and ARMD patients, but CCR2 levels were significantly 
      decreased on sALS but not on ARMD monocytes. Loss of monocyte CCR2 expression was 
      inversely correlated with degree of monocyte/macrophage activation in sALS and 
      this decrease was unlikely due to receptor down-regulation given the ARMD 
      results. Defective monocyte/macrophages may play an active role in sALS.
FAU - Zhang, Rongzhen
AU  - Zhang R
AD  - University of California, San Francisco, San Francisco General Hospital, San 
      Francisco, CA 94110, USA.
FAU - Gascon, Ron
AU  - Gascon R
FAU - Miller, Robert G
AU  - Miller RG
FAU - Gelinas, Deborah F
AU  - Gelinas DF
FAU - Mass, Jason
AU  - Mass J
FAU - Lancero, Mariselle
AU  - Lancero M
FAU - Narvaez, Amy
AU  - Narvaez A
FAU - McGrath, Michael S
AU  - McGrath MS
LA  - eng
GR  - U01-066529/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060720
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
RN  - 7LJ087RS6F (Riluzole)
SB  - IM
MH  - Aged
MH  - Amyotrophic Lateral Sclerosis/drug therapy/*metabolism
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Biomarkers/blood
MH  - Chemokine CCL2/blood
MH  - Drug Therapy, Combination
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Macrophage Activation/immunology
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*metabolism
MH  - Neuroprotective Agents/therapeutic use
MH  - Receptors, CCR2
MH  - Receptors, Chemokine/*biosynthesis
MH  - Riluzole/therapeutic use
EDAT- 2006/07/22 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/07/22 09:00
PHST- 2006/02/02 00:00 [received]
PHST- 2006/05/19 00:00 [revised]
PHST- 2006/06/12 00:00 [accepted]
PHST- 2006/07/22 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/07/22 09:00 [entrez]
AID - S0165-5728(06)00222-0 [pii]
AID - 10.1016/j.jneuroim.2006.06.008 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2006 Oct;179(1-2):87-93. doi: 10.1016/j.jneuroim.2006.06.008. 
      Epub 2006 Jul 20.